Results 141 to 150 of about 154,079 (202)

From political to democratic sophistication-A critical reappraisal. [PDF]

Br J Soc Psychol
Steinmetz K, Asbrock F.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

High-Sensitivity Terahertz Biosensor Based on a Multi-Layer Hybrid Structure Consisting of a Defect Mode and Graphene. [PDF]

Biosensors (Basel)
Hu H, Mo S, Deng Y, Zhao Z.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reserve of global constructive work for early diagnosis of myocardial ischemia and risk stratification in chronic coronary syndrome. [PDF]

Front Cardiovasc Med
Zhao R, Zhang J, Xie Y, Tan Y, Qi B, Bai L, Wu J, Cheng M, Wang X, Lv Q, Wang J, Xie M.   +11 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Two-factor synaptic consolidation reconciles robustness with pruning and homeostatic scaling. [PDF]

Proc Natl Acad Sci U S A
Iatropoulos G, Gerstner W, Brea J.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Development and validation of a nomogram prediction model for clinically significant prostate cancer combined with PI-RADS V2.1, MRI quantitative parameters and clinical indicators: a two-center study. [PDF]

Front Oncol
Chen Y, Yan L, Xianmei J, Heyi G, Wei X, Chao P, Yanwen D, Shicun D, Chao G, Cui Y, Peng G, Xiaodong L, Xiaoyu T, Bingbing L, Wenqing J, Kexian G, Qingqing L, Linglin Z, Yun Z, Lei Z, Jihong H, Wei Z, Yaying Y, Juan H.   +23 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source