Results 101 to 110 of about 1,873,361 (260)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Hα‐derived Star Formation Rates for Threez≃0.75 EDisCS Galaxy Clusters [PDF]

, 2005
Rose Finn, Dennis Zaritsky, Donald W. McCarthy, Bianca M. Poggianti, Gregory Rudnick, Claire Halliday, B. Milvang‐Jensen, R. Pelló, Luc Simard   +8 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Medial temporal lobe atrophy is associated with age and pathologies, especially small vessel disease. [PDF]

Sci Rep
van Westen D, Stomrud E, Lorenzini L, Palmqvist S, Barkhof F, Hansson O, Spotorno N.   +6 more
europepmc   +1 more source

Proniosomes derived niosomes: recent advancements in drug delivery and targeting [PDF]

, 2017
Maryam Khatoon, Kifayat Ullah Shah, Fakhar ud Din, Shefaat Ullah Shah, Asim Ur Rehman, Naz Dilawar, Ahmad Nawaz Khan   +6 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Development and Validation of a Novel Scoring Model Integrating Clinical Risk Factors and Pharmacokinetic Parameters to Predict Vancomycin-Induced Nephrotoxicity. [PDF]

Pharmacotherapy
Matsuki Y, Sako KI, Kozima Y, Watanabe T, Kashiwagura Y, Yasuno N, Watanabe S.   +6 more
europepmc   +1 more source

Chemical looping combustion of waste-derived fuel at 150 kW pilot-scale: Fuel conversion behavior and CO2 capture

Philipp Mohn, Inge Saanum, Øyvind Langørgen, Roger Khalil, Jochen Ströhle, Bernd Epple   +5 more
openalex   +1 more source

Identification and Functional Characterization of Tomato CircRNAs Derived from Genes Involved in Fruit Pigment Accumulation [PDF]

, 2017
Jinjuan Tan, Zhongjing Zhou, Yujie Niu, Xiaoyong Sun, Zhiping Deng   +4 more
openalex   +1 more source

Antifungal activity of Zinc nitrate derived nano Zno fungicide synthesized from Trachyspermum ammi to control fruit rot disease of grapefruit

, 2022
Musrat Ali, Xiukang Wang, Urooj Haroon, Hassan Javed Chaudhary, Asif Kamal, Qurban Ali, Muhammad Hamzah Saleem, Kamal Usman, Aishah Alatawi, Shafaqat Ali, Muhammad Farooq Hussain Munis   +10 more
openalex   +1 more source