Results 121 to 130 of about 186,731 (268)

Δ-β2M as a dynamic biomarker for predicting ICU admission after CAR T-cell therapy. [PDF]

Ann Hematol
Angleitner AC, Maulhardt M, Thomson K, Büntzel J, Wulf G.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Development and external validation of an ICU mortality prediction model using routinely collected clinical data. [PDF]

Medicine (Baltimore)
Zhu J, Xie Z, Liu J, Li C.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Qualified prediction system for allograft failure in real world settings: extended validation study. [PDF]

BMJ Med
Raynaud M, Truchot A, Naser S, Aubert O, Divard G, Thalamas T, Lombardi Y, Legendre C, Bailly E, Buchler M, Crespo M, Redondo D, Astor BC, Mandelbrot D, Parajuli S, Juric I, Basic-Jukic N, Helanterä I, Evans RDR, Sanghera A, Javed M, Molnar MZ, Yamauchi J, Fornadi K, Linhares K, Baujard M, Fowler KJ, Akalin E, Gupta G, Soler Pujol G, Tedesco-Silva H, Orandi BJ, Naesens M, Budde K, Naik M, Hertig A, Anglicheau D, Kamar N, Segev DL, Lefaucheur C, Loupy A.   +40 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Weighted risk scoring system for predicting peripartum transfusion: development and internal validation. [PDF]

Front Med (Lausanne)
Karakelleoğlu G, Kırımlı Yanık ECN, Üstün B, Erbakırcı NM, Çalışkan E.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients With <i>Staphylococcus aureus</i> Bacteremia. [PDF]

Open Forum Infect Dis
Péan de Ponfilly G, Beresteanu A, Chatellier G, Cachanado M, Shima M, Mizrahi A, Le Monnier A, Pilmis B.   +7 more
europepmc   +1 more source