Results 101 to 110 of about 373,844 (257)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On certain functional equation related to derivations
Open MathematicsIn this article, we prove the following result. Let n≥3n\ge 3 be some fixed integer and let RR be a prime ring with char(R)≠(n+1)!2n−2{\rm{char}}\left(R)\ne \left(n+1)\!{2}^{n-2}.
Marcen Benjamin, Vukman Joso
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Derivation of VO and OV takes a new look at the relationship between head-final or OV structures and head-initial or VO ones, in light of recent work by Richard Kayne and others.
Svenonius, Peter.
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Polysemy derivation in a multidimensional framework
, 2014 The aim of this paper is to systematise and illustrate the process of semantic network derivation within the multidimensional polysemy framework (Navarro, 1998, 2006) by way of a detailed analysis of the preposition into.
Silvestre-López, Antonio José
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Simplex Perfectives in Russian Verb Formation
LanguagesThis paper investigates the role of simplex perfectives in the Russian aspectual system, which are known to display a number of characteristics that seem to escape a proper theoretical treatment. It is proposed that simplex perfective roots (like reš- or
Olav Mueller-Reichau
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Symmetric Reverse n-Derivations on Ideals of Semiprime Rings
AxiomsThis paper focuses on examining a new type of n-additive map called the symmetric reverse n-derivation. As implied by its name, it combines the ideas of n-additive maps and reverse derivations, with a 1-reverse derivation being the ordinary reverse ...
Shakir Ali +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Conceptual and derivation systems [PDF]
, 2011 Pavel Materna proposed valuable explications of concept and conceptual system. After their introduction, we contrast conceptual systems with (a novel notion of) derivation systems. Derivation systems differ from conceptual systems especially in including
Raclavský, Jiří, Kuchyňka, Petr
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