Results 151 to 160 of about 303,092 (316)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Derivation-homomorphisms

open access: yes, 2016
In this paper, we introduce notions of (n, m)-derivation-homomorphisms and Boolean n-derivations.
Li, Lingyue, Xu, Xiaowei
core  

Kvantitativne lastnosti slovenskega tvorjenega besedja v poskusnem besednodružinskem slovarju za črko B

open access: yesSlavistična Revija, 2005
Prispevek predstavlja kvantitativne lastnosti v slovarju zajetega besedja, ki ga omogoča računalniški program SlovarRed 2.0, 2003 Tomaža Seliškarja in Sekcije za terminološke slovarje Inštituta za slovenski jezik Frana Ramovša, ZRC SAZU.
Irena STRAMLJIČ BREZNIK
doaj  

Derived tame and derived wild algebras

open access: yes, 2003
We prove that every finite dimensional algebra over an algebraically closed field is either derived tame or derived wild. We also prove that any deformation of a derived tame algebra is derived tame.
openaire   +5 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

On Constructing a Secure and Fast Key Derivation Function Based on Stream Ciphers

open access: yes
In order to protect electronic data, pseudorandom cryptographic keys generated by a standard function known as a key derivation function play an important role.
Alawatugoda, Janaka   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Derivation and Validation of a Risk Prediction Model for Vancomycin-Associated Acute Kidney Injury in Chinese Population

open access: yes, 2020
Nana Xu,1,2 Qiao Zhang,1,2 Guolan Wu,1,2 Duo Lv,1,2 Yunliang Zheng1,2 1Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Zhejiang Provincial
Xu N, Zheng Y, Lv D, Wu G, Zhang Q
core  

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