Results 231 to 240 of about 6,462,700 (311)

Development and external validation of the LEAN score to predict late seizures after intracerebral haemorrhage. [PDF]

Eur Stroke J
Reitsma FJ, van Kuijk SMJ, Werring DJ, Banerjee G, Cordonnier C, Kaaouana O, Puy L, Viswanathan A, van Oostenbrugge RJ, Staals J, Rouhl RPW.   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A clinical nomogram for predicting major adverse cardiovascular and cerebrovascular events in elderly Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention: development and validation in a real-world cohort. [PDF]

J Geriatr Cardiol
Xu JJ, Li QX, Yuan DS, Wang PZ, Hao YC, Zhu P, Song Y, Yao Y, Jiang L, Wang JY, Zhao XY, Song L, Yuan JQ, Zhang Y.   +13 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Validation of the PADIT (prevention of arrhythmia device infection trial) risk score for infection and infection subtypes. [PDF]

Europace
Golian M, Li Z, Berbenetz NM, Odabashian R, Sadek MM, Corrales-Medina V, Aydin A, Davis DR, Green MS, Klein A, Nair GM, Nery PB, Ramirez FD, Redpath C, Hansom SP, Edwards JD, Krahn AD, Birnie DH.   +17 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score. [PDF]

Rheumatology (Oxford)
Bruni C, Tofani L, Fretheim H, Liem SIE, Velauthapillai A, Bjørkekjær H, Barua I, Galetti I, Garaiman A, Becker MO, Hoffmann-Vold AM, de Vries-Bouwstra J, Vonk MC, Distler JHW, Matucci-Cerinic M, Distler O.   +15 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A causal forest model integrating quantitative CT scores to predict benefit from flexible bronchoscopy in pediatric Mycoplasma pneumoniae pneumonia: a two-center retrospective study. [PDF]

Respir Res
Ying Z, Li J, Li Z, Hu G, Yang F, Zhu Z, Han W, Zhu Z, Zhang B, Zhou Z, Duan M, Tan W, Li X, Jin Z, Song L, Yu G.   +15 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source