Results 261 to 270 of about 6,167,674 (361)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia. [PDF]

Crit Care Explor
Chen GS, Lee T, Tsang JLY, Binnie A, McCarthy A, Cowan J, Archambault P, Lellouche F, Turgeon AF, Yoon J, Lamontagne F, McGeer A, Douglas J, Daley P, Fowler R, Maslove DM, Winston BW, Lee TC, Tran KC, Cheng MP, Vinh DC, Boyd JH, Walley KR, Singer J, Marshall JC, Russell JA, Community-Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) Investigators.   +26 more
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Development and validation of a preoperative CT-based body composition nomogram for predicting recurrence-free survival after radical surgery in patients with gastric cancer. [PDF]

J Gastrointest Oncol
Song A, Huang Z, Xu J, Chen J, Gong H, Yang C, Zhu Z.   +6 more
europepmc   +1 more source

Derivation of naïve human embryonic stem cells

Proceedings of the National Academy of Sciences of the United States of America, 2014
C. Ware, Angelique M. Nelson, B. Mecham, Jennifer Hesson, Wenyu Zhou, Erica C. Jonlin, Antonio J. Jimenez-Caliani, Xinxian Deng, Christopher Cavanaugh, Savannah M Cook, P. Tesar, Jeffrey Okada, L. Margaretha, Henrik Sperber, Michael Choi, C. Blau, P. Treuting, R. D. Hawkins, V. Cirulli, H. Ruohola-Baker   +19 more
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Dose, Kidney Function, and a Drug-Excipient Interaction Impair Mycophenolate Mofetil Prodrug Activation in Kidney Transplant Recipients. [PDF]

Eur J Drug Metab Pharmacokinet
Nijdam FB, Hof MAJ, Kremer D, Knobbe TJ, Hopfgartner G, Bakker SJL, Hak E, Klont F, TransplantLines Investigators.   +8 more
europepmc   +1 more source

The physiological action of the alkaloids derived from Anhalonium Lewinii

, 1899
W. E. Dixon
openalex   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source