Primed bovine embryonic stem cell lines can be derived at diverse stages of blastocyst development with similar efficiency and molecular characteristics. [PDF]
Guiltinan C+5 more
europepmc +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Concomitant Sjögren's disease in patients with NMOSD: impacts on neurologic disease severity and recurrence. [PDF]
Wu W+8 more
europepmc +1 more source
Understanding and measuring mechanical signals in the tumor stroma
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz+3 more
wiley +1 more source
Early predictors of induction of remission with exclusive enteral nutrition in children with Crohn's disease. [PDF]
Hu Y+13 more
europepmc +1 more source
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He+5 more
wiley +1 more source
Retraction Note: Analytical investigations of propagation of ultra-broad nonparaxial pulses in a birefringent optical waveguide by three computational ideas. [PDF]
Liu Y+4 more
europepmc +1 more source
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi+2 more
wiley +1 more source
Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study. [PDF]
Liang T+12 more
europepmc +1 more source