Results 61 to 70 of about 5,342,052 (371)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
A New Measure of Monetary Shocks: Derivation and Implications
, 2003 Conventional measures of monetary policy, such as the federal funds rate, are surely influenced by forces other than monetary policy. More importantly, central banks adjust policy in response to a wide range of information about future economic ...
Christina D. Romer, D. Romer
semanticscholar +1 more source
Chemically defined conditions for human iPS cell derivation and culture
Nature Methods, 2011 We re-examine the individual components for human embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all protein reagents for liquid media, attachment surfaces and splitting are ...
Guokai Chen +14 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Open Mathematics, 2017 In calculus, an indefinite integral of a function f is a differentiable function F whose derivative is equal to f. The main goal of the paper is to generalize this notion of the indefinite integral from the ring of real functions to any ring.
Banič Iztok
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Derivation of English and Romanian Adjectives. A Contrastive Approach [PDF]
Journal of Humanistic and Social Studies, 2018 The study tackles the issue of Adjective derivation from a contrastive perspective. We have noticed that for Romanian learners of English as a Foreign Language, contrastive studies are a useful manner of understanding the similarities and the ...
Alina Ionescu (Padurean)
doaj
On Lie ideals satisfying certain differential identities in prime rings
Extracta Mathematicae, 2023 Let R be a prime ring of characteristic not 2, L a nonzero square closed Lie ideal of R and let F : R → R, G : R → R be generalized derivations associated with derivations d : R → R, g : R → R respectively.
B. Dhara, S. Ghosh, G.S. Sandhu
doaj