Results 111 to 120 of about 5,200,905 (357)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

(⊙, ∨)-Derivations on EMV-algebras and EBL-algebras

open access: yesRatio Mathematica
In the paper, we will study (∘, ∨)-derivations on EMV-algebras and EBL-algebras. Firstly, we define the notions of (∘, ∨)-derivations on EMV-algebras and EBL-algebras, and we also introduce some classes of (∘, ∨)-derivations on EMV-algebras and EBL ...
Tao Liu, Hongxing Liu
doaj   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

open access: yesFEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos   +3 more
wiley   +1 more source

Some results on Lattice involving generalized permuting tri-derivations

open access: yesBoletim da Sociedade Paranaense de Matemática
In this paper we introduce the notion of generalized permuting tri-derivations, g-derivations, and g-tri-derivations on lattices, and we study and generalize some properties discussed in [14] and [29].
Latifa Bedda   +2 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Generalized derivations on ideals of prime rings

open access: yes, 2013
Let R be a prime ring. By a generalized derivation we mean an additive mapping g W R! R such that g.xy/D g.x/yCxd.y/ for all x;y 2 R where d is a derivation of R.
E. Albaş
semanticscholar   +1 more source

Derived Brackets [PDF]

open access: yesLetters in Mathematical Physics, 2004
We survey the many instances of derived bracket construction in differential geometry, Lie algebroid and Courant algebroid theories, and their properties. We recall and compare the constructions of Buttin and Vinogradov, and we prove that the Vinogradov bracket is the skew-symmetrization of a derived bracket.
openaire   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

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