Results 91 to 100 of about 256,981 (277)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Boletim da Sociedade Paranaense de MatemáticaThis study presents a comprehensive investigation of soft and upper (lower) soft derivatives within the framework of Molodtsov’s soft set theory, extending it through the introduction of novel and complementary notions: left and right soft derivatives.
Enginoğlu, Serdar, Arslan, Burak
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Generalized Projective product of semi-rings
Wasit Journal of Computer and Mathematics ScienceThe concept of Differential algebra has been played an influential role in various directions of abstract algebra. This notation has been considered before fifty years ago with semi-ring and several types of rings.
mohd Shahoodh
doaj +1 more source
Generalized Derivations of BCC-Algebras
International Journal of Mathematics and Mathematical Sciences, 2013 The notion of generalized derivations of BCC-algebras is introduced, and some related properties are investigated. Also, we consider regular generalized derivations and the D-invariant on ideals of BCC-algebras.
S. M. Bawazeer +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On Inner Derivations of Leibniz Algebras
MathematicsLeibniz algebras are generalizations of Lie algebras. Similar to Lie algebras, inner derivations play a crucial role in characterizing complete Leibniz algebras.
Sutida Patlertsin +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
SSRN Electronic Journal, 2014 Dividend derivatives are not simply a by-product of equity derivatives. They constitute a distinct growing market and an entire suite of dividend derivatives are offered to investors. In this paper we look at two potential models for equity index dividends and discuss their theoretical and practical merits.
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source