Results 81 to 90 of about 5,311,848 (309)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Set Where an Approximate Derivative is a Derivative [PDF]

Proceedings of the American Mathematical Society, 1976
Let f : [ 0 , 1 ]
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

On derivations of pseudo L-algebras [PDF]

Journal of Mahani Mathematical Research
In this article, the focus is on the study of derivations on two types of algebraic structures: pseudo L-algebras and pseudo CKL-algebras. For pseudo L-algebras, the notions of left and right derivations are introduced.
Yu Qian Guo, Xiao Long Xin
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Local derivations on $C^*$-algebras are derivations [PDF]

Transactions of the American Mathematical Society, 2000
A local derivation \(T\) from a \(C^*\)-algebra \(\mathfrak A\) into a Banach bimodule \({\mathfrak X}\) (i.e., a continuous operator \(T:{\mathfrak A}\to{\mathfrak X}\) s.t. for any \(a\in{\mathfrak A}\) there is a derivation \(D_a\) from \({\mathfrak A}\) to \({\mathfrak X}\) with \(D_a(a)=T(a)\)) is actually a derivation. For von Neumann algebras \({
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

(⊙, ∨)-Derivations on EMV-algebras and EBL-algebras

Ratio Mathematica
In the paper, we will study (∘, ∨)-derivations on EMV-algebras and EBL-algebras. Firstly, we define the notions of (∘, ∨)-derivations on EMV-algebras and EBL-algebras, and we also introduce some classes of (∘, ∨)-derivations on EMV-algebras and EBL ...
Tao Liu, Hongxing Liu
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Relieving of Misconceptions of Derivative Concept with Derive

International Journal of Research in Education and Science, 2014
The purpose of this study is to determine students' learning levels in derivative subjects and their misconceptions. In addition, this study aims to compared to the effects of the computer based instruction and traditional instruction in resolving these misconceptions.
ÖZTÜRK, MESUT, ÖÇAL, MEHMET FATİH, KAPLAN, Abdullah   +2 more
openaire   +2 more sources