Results 111 to 120 of about 62,208 (302)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Generalized derivations on algebras
, 2002 In this paper we study (sigma,tau)-derivations on algebras from an abstract point of view. After some definitions and examples, we derive Leibniz type formulas and introduce a module structure on spaces of (sigma,tau)-derivations. Then we find all (sigma,
Harwig, Jonas, Silvestrov, Sergei
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Permuting tri-derivations on hyperrings
, 2020 In this paper we describe permuting tri-derivations in Krasner hyperrings. In this way we derive some important properties of permuting tri-derivations.
Ünal, Seda Oğuz
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Generalized (?, ß)-derivations in rings [PDF]
, 2010 Fen Bilimleri Enstitüsü, Matematik Ana Bilim DalıBu tez, türevli halkalar hakkında bir genelleştirme yapabilmek amacıyla hazırlanmıştır. Bu amaçla, Bölüm 3 de türevli halkalar, Bölüm 4 de ise (?, ß)-türevli halkalar ile ilgili genel ispatlara yer ...
Vurkaç, Selin
core +1 more source
, 2001 Rubach (2000) proposes a modified version of Optimality Theory (OT) that features derivations. While Prince and Smolensky's (1993) original formulation requires some modification, argue here that, rather than reintroducing derivations, the correct ...
Luigi Burzio
core +1 more source