Results 211 to 220 of about 305,961 (299)

Enhancing finite-difference based derivative-free optimization methods with machine learning [PDF]

Timothé Taminiau, Estelle Massart, Geovani Nunes Grapiglia   +2 more
openalex   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Enhanced Inhibition of <i>Trametes versicolor</i> by Structurally Modified Medicarpin: In Vitro Evaluation and In Silico Insights into Laccase Binding. [PDF]

Int J Mol Sci
Guevara-Martínez SJ, Rivera-Ramírez JD, Escutia-Gutiérrez R, Pérez-Cisneros MA, Villanueva-Mejía F, García-Zavala S, Herrera-Bucio R, Morales-Palacios FG.   +7 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Macrocycle-Assisted Cooperative Fe³⁺ Coordination and Fluorescence Regulation in a Coumarin-Functionalized Calix[4]arene. [PDF]

ACS Omega
Güngör Ö, Taşci N, Ünaldı AŞ, Durmuş M.   +3 more
europepmc   +1 more source

Microwave assisted Knoevenagel condensation : A facile method for the synthesis of 5-arylidine barbituric acid derivatives under solvent free conditions†

, 2007
S. S. Pandit, B. N. Jejurkar, R. L. Harde   +2 more
openalex   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Roles of Indole and Its Derivative in Modulating <i>E. coli</i>-<i>Candida albicans</i> Biofilm Formation. [PDF]

Int J Mol Sci
Ma YQ, Lin L.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Predefined-Time Sliding Mode Control of Robotic Manipulators via Artificial Delay Feedback and Reinforcement Learning. [PDF]

Sensors (Basel)
Zhang L, Wang J, Wang J, Lu J, Li P.
europepmc   +1 more source