Results 91 to 100 of about 62,722 (247)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Using regression trees for improving the efficiency of nonlinear programming solvers

Engineering Science and Technology, an International Journal
Optimization plays a critical role in fields such as economics, engineering, and computational sciences, where finding the optimal values of decision variables is essential for the design of a product, production system, or service system.
Fulya Terzi, Necati Aras, M. Gökçe Baydoğan   +2 more
doaj   +1 more source

Derivate Free Optimization

, 2014
During the last ten years, the speaker has developed Fortran software for minimizing general objective functions when first derivatives are not available. He has released two packages, namely NEWUOA and UOBYQA, for the unconstrained case and for simple upper and lower bounds on the variables, respectively.
openaire   +1 more source

Hierarchical planning-scheduling-control — Optimality surrogates and derivative-free optimization

Computers & Chemical Engineering
Planning, scheduling, and control typically constitute separate decision-making units within chemical companies. Traditionally, their integration is modelled sequentially, but recent efforts prioritize lower-level feasibility and optimality, leading to large-scale, potentially multi-level, hierarchical formulations.
Damien van de Berg, Nilay Shah, Ehecatl Antonio del Rio-Chanona   +2 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A partially derivative-free cyclic block coordinate descent method for nonseparable composite optimization

Mathematical Modelling and Analysis
In this paper, we address a composite optimization problem in which the objective function consists of two terms: the first presents a function with a gradient that satisfies a Lipschitz–Hölder composition, while the second one is a convex function ...
Vitaliano Amaral
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A new trust-region algorithm based on radial basis function interpolation

پژوهش‌های ریاضی, 2022
Optimization using radial basis functions as an interpolation tool in trust-region (ORBIT), is a derivative-free framework based on fully linear models to solve unconstrained local optimization, especially when the function evaluations are ...
Mohammad Ahmadvand, Mohsen Esmaeilbeigi, Ahmad Kamandi, Farajollah Mohammadi Yaghoobi   +3 more
doaj  

Query Complexity of Derivative-Free Optimization

, 2012
This paper provides lower bounds on the convergence rate of Derivative Free Optimization (DFO) with noisy function evaluations, exposing a fundamental and unavoidable gap between the performance of algorithms with access to gradients and those with access to only function evaluations.
Jamieson, Kevin G., Nowak, Robert D., Recht, Benjamin   +2 more
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source