Results 71 to 80 of about 66,605 (263)

Determining Convergence for Expected Improvement-Based Bayesian Optimization

Mathematics
Bayesian optimization routines may have theoretical convergence results, but determining whether a run has converged in practice can be a subjective task.
Nicholas R. Grunloh, Herbert K. H. Lee
doaj   +1 more source

A feasible method for constrained derivative-free optimization

Operations Research Letters
This paper explores a method for solving constrained optimization problems when the derivatives of the objective function are unavailable, while the derivatives of the constraints are known. We allow the objective and constraint function to be nonconvex.
Melody Qiming Xuan, Jorge Nocedal
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Gradual and Cumulative Improvements to the Classical Differential Evolution Scheme through Experiments

Annals of the West University of Timisoara: Mathematics and Computer Science, 2016
The paper presents the experimental results of some tests conducted with the purpose to gradually and cumulatively improve the classical DE scheme in both efficiency and success rate. The modifications consisted in the randomization of the scaling factor
Anescu George
doaj   +1 more source

Derivative-Free Optimization for Population Dynamic Models [PDF]

, 2015
Quantifying populations in changing environments involves fitting highly non-linear and non-convex population dynamic models to distorted observations. Derivatives of the objective function with respect to parameters might be expensive to obtain, unreliable or unavailable.
Ute Schaarschmidt, Trond Steihaug, Sam Subbey   +2 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Experimental Comparisons of Derivative Free Optimization Algorithms

CoRR, 2009
In this paper, the performances of the quasi-Newton BFGS algorithm, the NEWUOA derivative free optimizer, the Covariance Matrix Adaptation Evolution Strategy (CMA-ES), the Differential Evolution (DE) algorithm and Particle Swarm Optimizers (PSO) are compared experimentally on benchmark functions reflecting important challenges encountered in real-world
Anne Auger, Nikolaus Hansen, Jorge M. Perez Zerpa, Raymond Ros, Marc Schoenauer   +4 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Using Shortened Spin‐Ups to Speed Up Ocean Biogeochemical Model Optimization

Journal of Advances in Modeling Earth Systems
The performance of global ocean biogeochemical models can be quantified as the misfit between modeled tracer distributions and observations, which is sought to be minimized during parameter optimization.
S. Oliver, S. Khatiwala, C. Cartis, Ben Ward, Iris Kriest   +4 more
doaj   +1 more source