Results 61 to 70 of about 66,605 (263)
The Optimal Shape Parameter for the Least Squares Approximation Based on the Radial Basis Function
Mathematics, 2020 The radial basis function (RBF) is a class of approximation functions commonly used in interpolation and least squares. The RBF is especially suitable for scattered data approximation and high dimensional function approximation.
Sanpeng Zheng +2 more
doaj +1 more source
A derivative-free comirror algorithm for convex optimization [PDF]
Optimization Methods and Software, 2014 We consider the minimization of a nonsmooth convex function over a compact convex set subject to a nonsmooth convex constraint. We work in the setting of derivative-free optimization DFO, assuming that the objective and constraint functions are available through a black-box that provides function values for lower- representation of the functions ...
Heinz H. Bauschke +2 more
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 This paper describes a parameter-free free-form optimization method for reducing the radiated noise from vibrating shell structures in an open space. Squared sound pressure, which is evaluated by solving fully coupled shell-acoustic interaction system ...
Kensuke SHIMOIDE, Masatoshi SHIMODA
doaj +1 more source
Conquering the Worst Case of Infections in Networks
IEEE Access, 2020 We develop algorithms to control the scope of an infection spread on a network by allocating a fixed immunization budget to edges of the graph. We assume that the infection propagates according to an independent cascade model and interventions operate by
Wen Yan +4 more
doaj +1 more source
Derivative-free robust optimization by outer approximations
Mathematical Programming, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Matt Menickelly, Stefan M. Wild
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 This paper describes a parameter-free free-form optimization method for shell structures to reduce the noise in a closed acoustic field. Squared sound pressure, which is evaluated by solving fully coupled shell-acoustic interaction system, is selected as
Masatoshi SHIMODA, Kensuke SHIMOIDE
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source