Results 51 to 60 of about 66,605 (263)
Free-form optimization of shell structures for maximizing elastic buckling load
Nihon Kikai Gakkai ronbunshu, 2014 This paper presents a free-form optimization method for maximizing the elastic buckling load of a shell structure. A shell structure is assumed to be movable in the normal or the tangent direction to the surface for the shape optimization.
Masatoshi SHIMODA, Tomoki OKADA
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
A Direct Search Algorithm for Global Optimization
Algorithms, 2016 A direct search algorithm is proposed for minimizing an arbitrary real valued function. The algorithm uses a new function transformation and three simplex-based operations.
Enrique Baeyens +2 more
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Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas +3 more
wiley +1 more source
Entropy, 2013 Molecular modeling is an important subdomain in the field of computational modeling, regarding both scientific and industrial applications. This is because computer simulations on a molecular level are a virtuous instrument to study the impact of ...
Dirk Reith, Marco Hülsmann
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Pediatric Blood &Cancer, EarlyView.ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz +7 more
wiley +1 more source
A Second-Order Finite-Difference Method for Derivative-Free Optimization
Journal of MathematicsIn this paper, a second-order finite-difference method is proposed for finding the second-order stationary point of derivative-free nonconvex unconstrained optimization problems.
Qian Chen, Peng Wang, Detong Zhu
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
A Derivative-Free Geometric Algorithm for Optimization on a Sphere
CSIAM Transactions on Applied Mathematics, 2020 Summary: Optimization on a unit sphere finds crucial applications in science and engineering. However, derivatives of the objective function may be difficult to compute or corrupted by noises, or even not available in many applications. Hence, we propose a Derivative-Free Geometric Algorithm (DFGA) which, to the best of our knowledge, is the first ...
Chen, Yannan, Xi, Min, Zhang, Hongchao
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source