Results 41 to 50 of about 66,063 (262)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Improving derivative-free optimization algorithms through an adaptive sampling procedure
Results in Control and OptimizationBlack-box optimization plays a pivotal role in addressing complex real-world problems where the underlying mathematical model is unknown or expensive to evaluate.
Emmanouil Karantoumanis +1 more
doaj +1 more source
A Direct Search Algorithm for Global Optimization
Algorithms, 2016 A direct search algorithm is proposed for minimizing an arbitrary real valued function. The algorithm uses a new function transformation and three simplex-based operations.
Enrique Baeyens +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Entropy, 2013 Molecular modeling is an important subdomain in the field of computational modeling, regarding both scientific and industrial applications. This is because computer simulations on a molecular level are a virtuous instrument to study the impact of ...
Dirk Reith, Marco Hülsmann
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Algorithms, 2023 A derivative-free optimization (DFO) method is an optimization method that does not make use of derivative information in order to find the optimal solution. It is advantageous for solving real-world problems in which the only information available about
Zhongda Huang +5 more
doaj +1 more source
Derivative free optimization via repeated classification
CoRR, 2018 At ...
Tatsunori Hashimoto +2 more
openaire +3 more sources
Geometry of interpolation sets in derivative free optimization [PDF]
Mathematical Programming, 2006 The aim of the paper is to describe derivative free optimization methods and to prove their convergence. To compute new iterates in those methods a polynomial interpolation model of the objective function is minimized. An essential tool for proving convergence of those algorithms is an error bound between the interpolation model and the objective ...
Andrew R. Conn +2 more
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source