Results 131 to 140 of about 1,009,527 (289)

Teaching and learning strategies for the derivative in engineering education: A scoping review protocol. [PDF]

PLoS One
Galindo Illanes MK, Chamorro Manríquez DD, Herrera Valdés C.   +2 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Micropropagation of the Endemic <i>Stachys pinardii</i> Boiss. and Comparative Investigation of the Phytochemical Composition of Cultured and Wild-Grown Plants. [PDF]

Molecules
Üstüner H.
europepmc   +1 more source

Incomplete Derivative Markets and Portfolio Insurance [PDF]

We present necessary and sufficient conditions on the asset span of incomplete derivative markets for insuring marketed portfolios. If the asset span is finite dimensional there exists a polynomial-time algorithm for deciding if every marketed portfolio ...
Werner, J., Donald J. Brown, Charalambos Aliprantis   +2 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Modular Triethylene Glycol Decouples Antimicrobial Potency from Cytotoxicity in Membrane-Active Drugs. [PDF]

JACS Au
Seewald M, Stamen M, Li J, Engelkamp S, Behnke JS, Lucassen R, Borowick K, Weilburg M, Wycisk V, Fielitz T, Wu TC, Hartlieb M, Schaumburg F, Bockmühl D, Raisch T, Urner LH.   +15 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrated experimental and computational study of a novel indenonaphthodiazepine[5.3.3]propellane as a potential inhibitor of Mcl-1. [PDF]

Nanoscale Adv
Bijarbone SB, Bayat M, Gheidari D.
europepmc   +1 more source

Derivative-Based Acceleration of General Vector Machine

, 2019
General vector machine (GVM) is one of supervised learning machine, which is based on three-layer neural network. It is capable of constructing a learning model with limited amount of data.
Binbin Yong (20199993), Jun Shen (19588849), Fucun Li (20122506), Qingquan Lv (20220045), Qingguo Zhou (20190717)   +4 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source