Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing
ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Felix Bredendiek +2 more
wiley +1 more source
First gas chromatography-mass spectrometry (GC-MS) method for the detection and quantification of 11 trichothecenes and zearalenone in wheat plant-based beverages. [PDF]
Jia Z +6 more
europepmc +1 more source
Ion exchange HPLC microanalysis of chondroitin sulfate: quantitative derivatization of chondroitin lyase digestion products with 2-aminopyridine [PDF]
Anna Plaas +2 more
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Peach Kernel Oil Modulates Lipid Metabolism Disorder in ApoEa CRISPR/Cas9 Gene‐Disrupted Zebrafish
In this study, we used CRISPR/Cas9 gene editing technology to establish a lipid metabolism disorder model of ApoEa mutant zebrafish. We applied peach kernel oil to this model and studied the mechanism of peach kernel oil regulating lipid disorder in combination with transcriptomics.
Lei Xia +14 more
wiley +1 more source
Esterification of 3-quinuclidinol, a marker for the incapacitant BZ, for analysis by EI-GC-MS in OPCW test matrices. [PDF]
Cho DS, Baliu-Rodriguez D, Valdez CA.
europepmc +1 more source
A convenient tool for gas derivatization using fine-needle capillary mounting for protein crystals [PDF]
Nobuhiro Mizuno +2 more
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ABSTRACT In recent years, rising consumption of mushroom‐based foods has highlighted concerns over the formation of harmful Maillard reaction products (HMRPs) during thermal processing. However, limited information is available on the occurrence of intermediate and advanced HMRPs, such as α‐dicarbonyl compounds (α‐DCs) and advanced glycation end ...
Yong Li +9 more
wiley +1 more source
Development of an improved and greener HPLC-DAD method for the determination of fecal sterols in sediment and water samples using ultrasonic-assisted derivatization with benzoyl isocyanate. [PDF]
Effting LM, Teixeira Tarley CR.
europepmc +1 more source
Rational Design, Synthesis, and Catalytic Enantioselective Derivatization of an achiral ansa-Macrocycle [PDF]
Rui Wang
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Sea red rice bran polysaccharides were separated and purified by DEAE‐52 column chromatography, yielding three components: SRBP‐I, II, and III. Moreover, all three are pentosan‐type polysaccharides predominantly composed of mannose. Among them, SRBP‐I demonstrated the most potent inhibitory effect on HeLa cells. Further investigation indicated that the
Jianping Chen +8 more
wiley +1 more source

