Results 81 to 90 of about 141,863 (280)

Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization

Angewandte Chemie, EarlyView.
We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde, Jonatan Babiker, Michelle Mebrahtu, Anaïs Prigent, Gauthier Foucras, Yogesh N. Aher, Francoise M. Amombo Noa, Magnus J. Johansson, Janez Košmrlj, Ross D. Jansen‐van Vuuren, Thomas Cailly, Henrik Sundén   +11 more
wiley   +2 more sources

Triazolinediones as highly enabling synthetic tools [PDF]

, 2016
Triazolinediones (TADs) are unique reagents in organic synthesis that have also found wide applications in different research disciplines, in spite of their somewhat "exotic" reputation.
Billiet, Stijn, Chattopadhyay, Subrata, De Bruycker, Kevin, Du Prez, Filip, Houck, Hannes, Winne, Johan   +5 more
core   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Growth, Dissolution and Segregation of Genetically Encoded RNA Droplets by Ribozyme Catalysis

Angewandte Chemie, EarlyView.
Ribozymes enable sequence‐encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between genetic information and droplet behavior, marking a step toward programmable, evolvable RNA‐based compartments with life‐like properties.
Franziska Giessler, William Verstraeten, Tobias Abele, Stefan J. Maurer, Luca Monari, Kerstin Göpfrich   +5 more
wiley   +2 more sources

Spectrofluorimetric Method for the Determination of Tolterodine In Human Plasma and Pharmaceutical Preparations by Derivatization with Dansyl Chloride

Bezmiâlem Science, 2017
Objective:Tolterodine (TOL) is an anti-muscarinic drug used for the symptomatic treatment of urinary incontinence. Analytical methods in the literature are not sensitive enough for the assay of drug substance biological fluids. To make up the deficit, we
Şerife Evrim TEKKELİ
doaj   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Mechanochemical Synthesis of X‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes**

Angewandte Chemie, EarlyView.
The synthesis of a wide range of complex 1,2‐di(heteroatom)‐substituted (Z)‐alkenes is achieved through a mechanochemical one‐pot reaction of ethynylbenziodoxol(on)es (EBX/EBO) with a variety of heteroatom nucleophiles. The mechanochemical activation enables synthesis of a range of novel vinylbenziodoxol(on)es (VBX/VBO) whose synthesis is inefficient ...
Sayad Doobary, Judith Braunreuther, Andrew K. Inge, Berit Olofsson   +3 more
wiley   +2 more sources

Applications of Sample Preparation Techniques in the Analysis of New Psychoactive Substances

Separations
The global rise of new psychoactive substances (NPSs) poses challenges for their analysis in biological matrices due to their complex chemistries and short market lifespan. A comparative study for the simultaneous extraction, separation, and detection of
Lorna A. Nisbet, Fiona M. Wylie, Karen S. Scott   +2 more
doaj   +1 more source

The effect of salts on the derivatization and chromatography of amino acids [PDF]

Effect of salts on derivatization and chromatography of amino ...
Gehrke, C. W., Leimer, K.
core   +1 more source

Nitrogen‐Boosted H2O2 Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

Advanced Science, EarlyView.
PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang, Yaojia Yang, Aoxue Wang, Chen Shen, Shenliang Tan, Changsheng Liu, Yuzheng Zhao, Xue Qu   +7 more
wiley   +1 more source