Results 111 to 120 of about 9,396,792 (310)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Derived Categories of Hyper-Kähler Manifolds via the LLV Algebra. [PDF]
Milan J Math, 2022 Beckmann T.
europepmc +1 more source
Wielonurtowość polonistycznych badań językoznawczych. Próba typologii
Postscriptum Polonistyczne, 2020 The article aims at creating a schema that can be used to structure Polonistic linguistic research. The author suggests basic categories, such as METHODOLOGY and METHOD, SUBJECT and SOURCES.
Magdalena Pastuch
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Quantitative Morphometric Characteristics in the Geomorphic Setting of Southern Malang, Indonesia [PDF]
E3S Web of ConferencesGeomorphometry serves as a vital tool for providing quantitative data on watershed characteristics. Morphometric analysis is essential for understanding the relationship between landform features and hydrological responses. This research aimed to examine
Masruroh Heni +6 more
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Heisenberg Doubles and Derived Categories
Journal of Algebra, 1998 Let A be an abelian category of finite type and homological dimension 1. Then by results of Green R(A), the extended Hall-Ringel algebra of A, has a natural Hopf algebra structure. We consider its Heisenberg double Heis(A) and study its relation with D(A), the derived category of A.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Annales scientifiques de l'École normale supérieure, 1994 The author investigates the derived category of a differential \(\mathbb{Z}\)- graded category. As applications: 1. a ``triangulated analogue'' of a theorem of \textit{P. Freyd} [``Abelian Categories'', Harper \& Row (1964; Zbl 0121.021)] and \textit{P. Gabriel} [Bull. Soc. Math. France 90, 323-448 (1962; Zbl 0201.356)] characterizing module categories
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source