Results 31 to 40 of about 59,772 (269)

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

open access: yesJournal of Experimental & Clinical Cancer Research, 2018
Background Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved
Maria Elena Pisanu   +19 more
doaj   +1 more source

Successful use of dupilumab for treatment-resistant pityriasis amiantacea

open access: yesJournal of Dermatology and Dermatologic Surgery, 2022
Pityriasis amiantacea (PA) is a scalp condition characterized by thick, adherent scales that are silvery or yellow–gray in color and bind down tufts of hair. PA is associated with several underlying dermatologic conditions including psoriasis, seborrheic
Maya Firsowicz   +3 more
doaj   +1 more source

Erythema annulare centrifugum-like eruption associated with pegylated interferon treatment for hepatitis C

open access: yesDermatology Reports, 2013
Current standard of treatment for chronic hepatitis C virus infection requires the use of pegylated interferon plus ribavirin. Treatment with these two agents has been associated with numerous side effects, which frequently include dermatologic eruptions.
Mark Naccarato   +3 more
doaj   +1 more source

Federated Contrastive Learning for Dermatological Disease Diagnosis via On-device Learning [PDF]

open access: yesarXiv, 2022
Deep learning models have been deployed in an increasing number of edge and mobile devices to provide healthcare. These models rely on training with a tremendous amount of labeled data to achieve high accuracy. However, for medical applications such as dermatological disease diagnosis, the private data collected by mobile dermatology assistants exist ...
arxiv  

Towards Transparency in Dermatology Image Datasets with Skin Tone Annotations by Experts, Crowds, and an Algorithm [PDF]

open access: yesarXiv, 2022
While artificial intelligence (AI) holds promise for supporting healthcare providers and improving the accuracy of medical diagnoses, a lack of transparency in the composition of datasets exposes AI models to the possibility of unintentional and avoidable mistakes.
arxiv  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

open access: yesAngewandte Chemie, EarlyView.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano   +2 more
wiley   +2 more sources

DermSynth3D: Synthesis of in-the-wild Annotated Dermatology Images [PDF]

open access: yesarXiv, 2023
In recent years, deep learning (DL) has shown great potential in the field of dermatological image analysis. However, existing datasets in this domain have significant limitations, including a small number of image samples, limited disease conditions, insufficient annotations, and non-standardized image acquisitions.
arxiv  

Light‐Activatable Hyaluronic Acid‐Derivatives Releasing Nitric Oxide and Their Delivery in the Skin

open access: yesAdvanced Healthcare Materials, EarlyView.
This work explores the development of photoactivatable hyaluronic acid (HA) derivatives functionalized with nitric oxide (NO) photodonors for light‐controlled therapeutic applications. The HA derivatives demonstrate enhanced keratinocyte proliferation and migration, effective NO release, and skin penetration when formulated as microemulsions.
Giuseppe Longobardi   +7 more
wiley   +1 more source

Potential drug interactions in dermatologic outpatient prescriptions—experience from nationwide population-based study in Taiwan

open access: yesDermatologica Sinica, 2011
Background: Adverse drug reactions increase morbidity and mortality, and potential drug interactions (DIs) increase the probability of adverse drug reactions.
Ying-Jui Chang   +6 more
doaj   +1 more source

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