Results 31 to 40 of about 17,787 (263)

Tough Injectable Hydrogels Enabled by Integrating Rigid Homogeneous Framework With Flexible Chains

Advanced Functional Materials, EarlyView.
Tough injectable hydrogels are constructed by integrating a rigid, homogeneous hyaluronic acid framework with flexible long‐chain connectors. This framework–flexible structure simultaneously enhances network uniformity and promotes effective energy dissipation by enlarging plastic deformation zones under compression.
Rijian Song, Runqi Zhu, Cameron Milne, Melissa Johnson, Chunyu Zhao, Qiang Geng, Yinghao Li, Jing Lyu, Qiang Li, Sigen A, Wenxin Wang   +10 more
wiley   +1 more source

Vincristine-Induced Acrocyanosis and Erythema Pernio

Journal of Primary Care & Community Health, 2023
Introduction: Acrocyanosis and erythema pernio are 2 dermatologic manifestations of vasospastic changes. Primary care providers should consider that these conditions can occur as primary or idiopathic conditions and as secondary conditions related to ...
Hayden T. Middleton, Christopher L. Boswell, Elisa J. Houwink, Wendy A. Allen-Rhoades, Alexis K. Kuhn, Jessica A. Wright   +5 more
doaj   +1 more source

Mimicking Human Perspiration: A Layered Microfluidic Skin Phantom With Tunable Hydrodynamics

Advanced Materials Interfaces, EarlyView.
A multilayer microfluidic skin phantom based on thermoplastic elastomers is developed to mimic human perspiration. Spatially controlled wettability enables capillary‐driven transport and controlled droplet formation at the surface, resembling sweat gland behavior.
Chunyu Yang, Ángeles Ivón Rodríguez‐Villarreal, Joan Antoni López‐Martínez, Josep Farré‐Lladós, Genís Rabost‐García, Jasmina Casals‐Terré   +5 more
wiley   +1 more source

Treatment‐Related Adverse Events and Associated Outcomes in Patients With Advanced Urothelial Carcinoma Treated With Enfortumab Vedotin: Analysis of the UNITE Study

Cancer Medicine
Introduction Enfortumab vedotin‐ejfv (EV), an antibody–drug conjugate approved for advanced urothelial carcinoma (aUC), has limited real‐world safety data and no validated predictive biomarkers.
Amanda Nizam, Charles B. Nguyen, Jinju Li, Emily C. Zabor, Pavlos Msaouel, Cindy Y. Jiang, Omar Alhalabi, Eugene Oh, Matthew P. Davidsohn, Ilana B. Epstein, Dimitra Rafailia Bakaloudi, Rafee Talukder, Tanya Jindal, Amy K. Taylor, Michael J. Glover, Ali Raza Khaki, Emily Lemke, Hannah Mabey, Bashar Abuqayas, Albert Jang, Jason R. Brown, Sean T. Evans, Cameron Pywell, Arnab Basu, Mehmet A. Bilen, Pedro C. Barata, Yousef Zakharia, Matthew I. Milowsky, Deepak Kilari, Christopher J. Hoimes, Sumit A. Shah, Hamid Emamekhoo, Nancy B. Davis, Shilpa Gupta, Petros Grivas, Joaquim Bellmunt, Matthew T. Campbell, Ajjai S. Alva, Vadim S. Koshkin   +38 more
doaj   +1 more source

Treatment Strategies for Cutaneous and Oral Mucosal Side Effects of Oncological Treatment in Breast Cancer: A Comprehensive Review

Biomedicines
Cutaneous and oral mucosal adverse events (AEs) are among the most common non-hematologic toxicities observed during breast cancer treatment. These complications arise across various therapeutic modalities including chemotherapy, targeted therapy ...
Sanja Brnić, Bruno Špiljak, Lucija Zanze, Ema Barac, Robert Likić, Liborija Lugović-Mihić   +5 more
doaj   +1 more source

Erythema annulare centrifugum-like eruption associated with pegylated interferon treatment for hepatitis C

Dermatology Reports, 2013
Current standard of treatment for chronic hepatitis C virus infection requires the use of pegylated interferon plus ribavirin. Treatment with these two agents has been associated with numerous side effects, which frequently include dermatologic eruptions.
Mark Naccarato, Deborah Yoong, Robert Solomon, Mario Ostrowski   +3 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

A Closer Look at the Dermatological Profile of GLP-1 Agonists

Diseases
Background/objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in treating type 2 diabetes and obesity, offering established metabolic and cardiovascular benefits.
Calista Persson, Allison Eaton, Harvey N. Mayrovitz   +2 more
doaj   +1 more source

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved
Maria Elena Pisanu, Marcello Maugeri-Saccà, Luigi Fattore, Sara Bruschini, Claudia De Vitis, Eugenio Tabbì, Barbara Bellei, Emilia Migliano, Daniela Kovacs, Emanuela Camera, Mauro Picardo, Ziga Jakopin, Claudia Cippitelli, Armando Bartolazzi, Salvatore Raffa, Maria Rosaria Torrisi, Franco Fulciniti, Paolo A. Ascierto, Gennaro Ciliberto, Rita Mancini   +19 more
doaj   +1 more source