Results 61 to 70 of about 28,315 (303)

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Role of ASLNC168501 in regulating hair follicle stem cell activity via the AR/miR-128-3p/IGF-1 pathway

Stem Cell Research & Therapy
Background Hair follicle stem cells (HFSCs) in androgenetic alopecia (AGA) patients exhibit functional impairment, reduced quantity, dysregulation, and androgen sensitivity, which hinder therapeutic strategies targeting HFSCs activation for hair ...
Xuewen Chen, Jingxiu Chai, Xuan Wang, Leimeng Gan, Qing Zhang, Hao Luo, Ling Wu, Yuchong Chen   +7 more
doaj   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Pachydermodactyly: An Underdiagnosed Condition in Adolescence—A Case Report and Literature Review

Case Reports in Dermatological Medicine
Pachydermodactyly (PDD) is a rare, underdiagnosed benign condition characterized by asymmetrical, bilateral fusiform swellings of the hands’ proximal interphalangeal (PIP) joints.
Mishari T. Alrubaiaan, Yousef H. Alharthi, Suliman Alfaraj   +2 more
doaj   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

The Reverse Galeal Hinge Flap: Another Valuable Technique in the Repair of Scalp Defects Extending to the Calvarium [PDF]

, 2015
Over the last 30 years, the estimated incidence of nonmelanoma skin cancer (NMSC) has increased from 300,000 to greater than 2 million cases. Approximately 15% of these cancers occur on the scalp.1 Given the increasing incidence of NMSC and their ...
Bingham, Jonathan L., Lam, Thomas, Miletta, Nathanial R.   +2 more
core   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Cancer-related fatigue in dermatologic surgery

JAAD Reviews
Cancer-related fatigue (CRF) is a well-recognized phenomenon in oncology, yet it remains unexplored in dermatologic surgery and cutaneous oncology. CRF is a distressing sense of physical, emotional, and cognitive tiredness related to cancer and its ...
Frank Z. Jing, MD, Elliott H. Campbell, MD, Allison Robbins, MD, Ally-Khan Somani, MD, PhD, Jerry D. Brewer, MD, MS, Michael Kunz, MD, Nahid Y. Vidal, MD   +6 more
doaj   +1 more source

Dermatosurgical rounds: double opposing rotational advancement (Ying-Yang) flap for reconstruction of primary defects following skin cancer excisions in the medial foot ankle and preauricular regions [PDF]

Folia Medica
Surgical reconstructive techniques continue to evolve as dermatosurgeons combine clinical expertise, technical skill, and innovation. In some cases, such innovation can result in better outcomes in terms of tension management, vascular supply ...
Simona Kordeva, Konstantin Georgiev Tchernev Jr, Georgi Tchernev   +2 more
doaj   +3 more sources

Dermatological Malignancies at a University Teaching Hospital in north-western Tanzania: A Retrospective Review of 154 Cases [PDF]

, 2012
Dermatological malignancies are among the most common form of cancers and the global incidence has been increasing at an alarming rate. A retrospective study was conducted to determine the prevalence, histopathological pattern, anatomical distribution ...
Chalya, Phillipo L., Gilyoma, Japhet M., Kahima, Kahima J., Kanumba, Emmanuel S., Masalu, Nestory, Mawala, Brian, Rambau, Peter   +6 more
core   +2 more sources