Results 71 to 80 of about 11,135 (284)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Suporte básico de vida e suporte avançado de vida em cardiologia: proposta de uma nova estratégia para abordagem e prevenção das intercorrências clínicas em cirurgia dermatológica Basic life support and advanced cardiac life support: proposal of a new strategy to approach and prevent clinical events in dermatologic surgery

Anais Brasileiros de Dermatologia, 2010
Com o aumento da complexidade cirúrgica e comorbidades da população, o risco de intercorrências clínicas em cirurgia dermatológica aumentou nas últimas décadas.
Fábio Roismann Timoner, Nelson Marcos Ferrari, Manoel Carlos Sampaio de Almeida Ribeiro, Frida Liane Plavnik, Carlos d'Aparecida Santos Machado Filho   +4 more
doaj   +1 more source

Hairy Tongue [PDF]

, 2017
Hairy tongue (lingua villosa) is a commonly observed condition of defective desquamation of the filiform papillae that results from a variety of precipitating factors. [1] The condition is most frequently referred to as black hairy tongue (lingua villosa
Burgess, Jeff, Butler, David F., Eisen, Drore, Handler, Marc Zachary, Lynch, Denis P, Stafford, Gary L   +5 more
core   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Local anesthetic infiltration vs. nervous blocks in face’s skin lesions: what’s new [PDF]

, 2018
Skin tumors are the most common type of cancer. They are localized throughout the body, more frequently in those regions chronically exposed to sun, like face, scalp and neck, compromising aesthetic appearance.
Arrico, L., Brancadoro, D., Collini, S., Grippaudo, F., Troisi, F.   +4 more
core  

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Incomplete Excision Rate for Lentigo Maligna and Associated Risk Factors

Acta Dermato-Venereologica
Standard treatment for lentigo maligna (LM) is surgical excision, yet insights into the frequency of and risk factors for incomplete excisions remain limited.
Maja Modin, Helena Svensson, Ylva Bergsten Wanders, Noora Neittanmäki, Jan Siarov, John Paoli   +5 more
doaj   +1 more source

Managing for change: July 9, 1991 v. 2, no. 4 [PDF]

, 1991
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Abercrombie, J. Scott, Jr., Boston University Medical Center, Office of Publication Services   +1 more
core  

Basal cell carcinoma: 10-year experience with electrochemotherapy [PDF]

, 2017
BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy.
Alaibac, MAURO SALVATORE ALESSANDRO, Campana, LUCA GIOVANNI, Galuppo, Sara, Marconato, Roberto, Mocellin, Simone, Rossi, CARLO RICCARDO, Valpione, Sara   +6 more
core   +2 more sources