Results 91 to 100 of about 38,153 (235)

Possible involvement of keratinocyte‐derived microvesicle particles in human photosensitivity disorders

Photochemistry and Photobiology, EarlyView.
In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Risha Annamraju, Madison S. Owens, Anita Thyagarajan, Danielle A. Corbin, Catherine M. T. Sherwin, Jade Bryant, Garrett W. Fisher, Winston R. Owens, Alycia Ketter, Aadil Umerani, Craig A. Rohan, Michael G. Kemp, Robyn K. Crow, Jeffrey B. Travers   +13 more
wiley   +1 more source

Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report

Journal of Cardiothoracic Surgery, 2018
Background Dermatomyositis, an inflammatory myopathy with cutaneous involvement, is associated with malignancy and often manifests paraneoplastically. While co-occurrence with small cell carcinoma is well attested, primary lung adenocarcinoma, which may ...
Andrew J. Beel, David S. Demos, Alfred Chung, Charles Liao, Natalie S. Lui   +4 more
doaj   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Differential clinical features of patients with clinically amyopathic dermatomyositis who have circulating anti-MDA5 autoantibodies with or without myositis-associated autoantibodies [PDF]

, 2018
学位記番号 ...
Yamaguchi, Koichi, ヤマグチ, コウイチ, 山口, 公一   +2 more
core  

Inflammatory Myopathies with Cutaneous Involvement: from Diagnosis to Therapy

Folia Medica, 2017
The group of idiopathic inflammatory myopathies (IIM) include various disorders of skeletal muscles with or without skin involvement. The most common types are dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and necrotizing ...
Dourmishev Lyubomir A.
doaj   +1 more source

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Amanda D. Robinson, Clare E. Pain, Gabrielle A. Morgan, Anwesha Sanyal, Srilakshmi Chaparala, Lauren M. Pachman, Kathryn S. Torok   +6 more
wiley   +1 more source

Atypical presentation of anti-small ubiquitin-like modifier 1 and melanoma differentiation-associated gene 5 antibody positive dermatomyositis presenting with significant inflammatory myopathy on biopsy and normal creatine kinase levels: A case report

SAGE Open Medical Case Reports
Idiopathic inflammatory myopathies are characterized by chronic inflammation of skeletal muscle. The main subtypes of idiopathic inflammatory myopathies include dermatomyositis, polymyositis, and necrotizing autoimmune myopathies.
Srikar Sama, Nidaa Rasheed, Kyle Shen, Negar Khanlou, Karam Han, Alicia Rodriguez-Pla   +5 more
doaj   +1 more source

Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report

Journal of Medical Case Reports, 2009
Introduction Dermatomyositis is an important inflammation of skin and muscles. Generalised itch is frequent in the condition; however, symptomatic dermographism has not previously been reported as a presenting feature.
Rahim Kartini F, Dawe Robert S
doaj   +1 more source

Reliability and Construct Validity of the Physician's Global Assessment of Lung Disease in Systemic Juvenile Idiopathic Arthritis–Associated Lung Disease

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective The physician global assessment of lung disease (PGALD) is a recently proposed disease activity measure for patients with systemic juvenile idiopathic arthritis–associated lung disease (SJIA‐LD). This study evaluates the reliability and construct validity of the PGALD.
Eileen Rife, Guihua Zhai, Mekibib Altaye, Jennifer Andringa, Hermine I. Brunner, Scott Canna, Lauren A. Henderson, Yukiko Kimura, Scott M. Lieberman, Mona Riskalla, Christopher Towe, Tiphanie Vogel, Holly Wobma, Grant Schulert, for the PGALD Validation Consortium Investigators, Rabheh Abdul Aziz, Sheila Angeles‐Han, Kevin Baszis, Edward Behrens, Hermine I. Brunner, Gregory Burg, Scott Canna, Alicia Casey, Matthew Clark, Dominic Co, Kathleen Collins, Randy Cron, Marietta DeGuzman, Fatma Dedeoglu, Robin Deterding, Barbara Eberhard, Deanna Green, Timothy Hahn, Daniel M. Hinds, Patricia Hobday, Sandy Hong, Aimee Hersh, Jennifer Huggins, Yukiko Kimura, Susan Kim, Marisa Klein‐Gitelman, Daniel Lovell, Patricia Lu, Melissa Mannion, Jessica Neely, Michael O'Connor, Karen Onel, Amir Orandi, Andrea Ramirez, Adam Reinhard, Mona Riskalla, Steven Rose, Kristen Ruff, Laisa Santiago, Vivian Saper, Susan Shenoi, Manuel Silva‐Carmona, Emily Smitherman, David R. Spielberg, Jade Tam‐Williams, Christopher Towe, Tracy Ting, Fernando Urrego, Timothy Vece, Tiphanie Vogel, Jennifer Weiss, Holly Wobma, Lauren A. Henderson, Scott M. Lieberman, Julian Vyas, Lisa Young   +70 more
wiley   +1 more source