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High throughput drug discovery towards novel therapeutics for snakebite dermonecrosis
2023Snakebite envenomation is a neglected tropical disease that kills over 100,000 people per year and injures more than 400,000. Brazil suffers more than 26,000 snakebites per year. It is estimated that 90% of all snakebite accidents in the Amazon region are caused by Bothrops species pit vipers.
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Vaccine, 2017
Staphylococcus aureus is a very important human pathogen that causes significant morbidity and mortality worldwide. Several vaccine clinical trials based on generating antibody against staphylococcal surface polysaccharides or proteins have been unsuccessful.
Fan, Zhang +5 more
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Staphylococcus aureus is a very important human pathogen that causes significant morbidity and mortality worldwide. Several vaccine clinical trials based on generating antibody against staphylococcal surface polysaccharides or proteins have been unsuccessful.
Fan, Zhang +5 more
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[Enzootic dermonecrosis in chickens].
Veterinarno-meditsinski nauki, 1976An enzootic of necrotic dermatosis in hen layers was described. The changes consisted in that they had constant localization and demarkated sites on the skin between the back and the neck. The disease was observed on a farm for 5000 layers in the course of two consecutive years.
R, Kasabov, S, Nachev
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Biochemical and Biophysical Research Communications, 1998
The bite of spiders of the genus Loxosceles can induce a variety of biological effects, including dermonecrosis and complement (C) dependent haemolysis. The aim of this study was to characterise the toxins in the venom responsible for the different biological effects.
D V, Tambourgi +6 more
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The bite of spiders of the genus Loxosceles can induce a variety of biological effects, including dermonecrosis and complement (C) dependent haemolysis. The aim of this study was to characterise the toxins in the venom responsible for the different biological effects.
D V, Tambourgi +6 more
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A case report of conjunctivitis and dermonecrosis in rabbit due to Staphylococcus aureus.
Bhambani Bd
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Toxicon, 2015
Envenomation caused by spiders Loxosceles induce intense dermonecrosis at the bite site and systemic disease. In this work we described the hyaluronidase and collagenase activities in vitro of the Loxosceles intermedia venom, but no phospholipase A2 activity. In vivo, we evaluated the effect of L. intermedia venom used different strain of mice, C57BL/6,
M.F. Ribeiro +7 more
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Envenomation caused by spiders Loxosceles induce intense dermonecrosis at the bite site and systemic disease. In this work we described the hyaluronidase and collagenase activities in vitro of the Loxosceles intermedia venom, but no phospholipase A2 activity. In vivo, we evaluated the effect of L. intermedia venom used different strain of mice, C57BL/6,
M.F. Ribeiro +7 more
openaire +2 more sources

