Results 191 to 200 of about 766,795 (285)

Estado de progreso en el desarrollo de proyectos software apoyado por Semat y QFD

Ingeniare: Revista Chilena de Ingeniería
El éxito en el desarrollo de un proyecto de software consiste en cumplir con los objetivos para los cuales fue concebido. Un aspecto fundamental radica en medir el estado de progreso del proyecto a través del seguimiento, determinando qué controles se ...
Luis Fernando Castro Rojas, Esperanza Espitia Peña   +1 more
doaj  

Testing the Island Effect in a Highly Mobile Pollinator: Wing Morphological Divergence in Euglossa mixta from Continental and Insular Panama. [PDF]

Animals (Basel)
Añino Y, Hernández-Martelo J, Moya F, Piñeiro-González A, Pérez LM, Gálvez D, Vega-Rovira Y, Trujillo J, Garrido A, Arrocha D, Cruz-Jofré F, Benítez HA.   +11 more
europepmc   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

An Untargeted Metabolomic Approach to Characterize the Emerging Kernel Disorder "Orange Spot" in Walnut (<i>Juglans regia</i> L.) cv. Chandler. [PDF]

Metabolites
Hernández I, Ponce E, Vidal J, Núñez-Lillo G, Dorochesi F, Pedreschi R, Fuentealba C.   +6 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Correction: Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study. [PDF]

Front Aging Neurosci
Maldonado-Díaz M, Jara-Vargas G, González-Seguel F.   +2 more
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

SMELLWARE: un juego para la enseñanza de buenas prácticas en el proceso de desarrollo de software

Ingeniare: Revista Chilena de Ingeniería
En el contexto del desarrollo de software, los smells son porciones de código fuente que sugieren la presencia de problemas más profundos, como el código duplicado.
Carlos Mario Zapata Jaramillo, María Clara Gómez Álvarez, Juan Carlos Hernández Palencia   +2 more
doaj  

Immune system up-regulation in securely attached infants during early childhood. [PDF]

Brain Behav Immun Health
González-Puelma J, Sarmiento Varón L, Vidal J, Ceroni C, Escobedo S, Uribe-Paredes R, Medina-Ortiz D, Cárcamo RA, Navarrete MA.   +8 more
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source