Results 191 to 200 of about 400,448 (292)

Aortic Atresia With Ventricular Septal Defect and Normal-Sized Left Ventricle Mimicking Truncus Arteriosus. [PDF]

Case Rep Cardiol
Ho CL, Chow PC.
europepmc   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Subclavian VA-ECMO-Supported TAVR and Rotational Atherectomy in Cardiogenic Shock. [PDF]

JACC Case Rep
Fukamachi D, Fujito H, Matsumoto N, Okumura Y.   +3 more
europepmc   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Expression of Concern: Health risk implications of iron in wastewater soil-food crops grown in the vicinity of peri urban areas of the District Sargodha. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery

Advanced Science, EarlyView.
DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang   +8 more
wiley   +1 more source

Beyond Wellens' Syndrome: Two Cases of Dynamic Electrocardiographic (ECG) Changes in Critical Left Anterior Descending Coronary Artery (LAD) Occlusion. [PDF]

Cureus
Nikolov NN, Grigorov RK, Yambolov SN, Yankov YG.   +3 more
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Transaortic TAVR and MICS-CABG in a Patient on Dialysis With RCA Restenosis. [PDF]

JACC Case Rep
Sai Y, Kikuchi K, Sakai H, Yoshino K, Noguchi M, Ito J.   +5 more
europepmc   +1 more source