Results 111 to 120 of about 67,996 (272)

The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon

Pesquisa Veterinária Brasileira, 2012
This study reports on changes in the number of somatostatin-like immunoreactive (SOM-LI) endocrine cells in the porcine descending colon, caused by chemically driven inflammation, axotomy and proliferative enteropathy (PE).
Sławomir Gonkowski, Jarosław Całka   +1 more
doaj   +3 more sources

Laparoscopic surgery for colorectal cancer with persistent descending mesocolon

World Journal of Surgical Oncology, 2019
Background Persistent descending mesocolon (PDM) is caused by the absence of fusion of the descending colon to the retroperitoneum. We herein report two colorectal cancer cases with PDM that were treated with laparoscopic surgery.
Yukiharu Hiyoshi, Yuji Miyamoto, Kojiro Eto, Yohei Nagai, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Hideo Baba   +8 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269

Cancer Science, EarlyView.
CD40 agonists have demonstrated proof‐of‐concept for converting an immunologically cold tumor into a hot tumor in preclinical studies; however, clinically, they have shown limited antitumor efficacy as monotherapy. We tested a tumor‐targeted CD40 agonist, KK2269 (a bispecific antibody that binds to CD40 and EpCAM), in combination with various ...
Yuta Tezuka, Kyoko Kawasaki, Yoshiki Sumitomo, Masato Saito, Akari Yao, Munetoshi Ando   +5 more
wiley   +1 more source

Phenotypic Expansion and Molecular Implications in Recessive FUZ‐Related Ciliopathy

Clinical Genetics, EarlyView.
Our patient with homozygous FUZ p.Arg234Trp, potentially altering FUZ‐CPLANE2 interactions, presented with aorto‐pulmonary window, Hirschsprung disease, and shared phenotypes with previously reported ciliopathy patients. This report provides additional evidence for FUZ as a causative gene for ciliopathy, offering novel insights into the phenotype ...
Yosuke Ogawa, Shota Kato, Kazuhiro Shiraga, Motohiro Kato, Ryo Inuzuka   +4 more
wiley   +1 more source

Stapled side‐to‐side anastomosis to treat a pelvic flexure stricture in a miniature horse

Equine Veterinary Education, EarlyView.
Summary Fecaliths are a recognised cause of non‐strangulating colon obstruction in horses. Although they more commonly obstruct the small colon, they can also lodge in the pelvic flexure, requiring enterotomy for removal. Stricture at the enterotomy site is an uncommon but surgically significant complication.
M. Baglioni, N. Berka, P. Matrat, L. Legrand, L. Borde‐Dore, C. de Chaisemartin   +5 more
wiley   +1 more source

Dysplasia in sessile serrated lesions: frequency, interobserver variability and added value of immunohistochemistry

Histopathology, EarlyView.
Sessile serrated lesions with dysplasia represent a critical step in colorectal carcinogenesis. While routine histologic diagnosis is generally reliable and positive diagnostic trends are observed, subtle dysplastic changes may be overlooked. Targeted use of MLH1 immunohistochemistry provides meaningful diagnostic support in selected sessile serrated ...
Valentina Angerilli, M. Elisa Vink‐Börger, Nanette S. van Roermund, Gesina van Lijnschoten, Chantal C.H.J. Kuijpers, Nicole C.T. van Grieken, Matteo Fassan, Joep E. Ijspeert, Rachel S. van der Post, Iris D. Nagtegaal   +9 more
wiley   +1 more source

Drug‐induced hypersensitivity syndrome followed by exacerbation of Crohn's disease

Pediatric Investigation, EarlyView.
Mei Kamidani, Ryo Tanaka, Hiroshi Oue, Risa Fukuda, Rena Hashimoto, Ichiro Takeuchi, Takako Yoshioka, Naoya Tonegawa, Akira Ishiguro, Katsuhiro Arai, Kazue Yoshida   +10 more
wiley   +1 more source

The junction between the midgut and hindgut co‐localizes with the rectosigmoid junction

Journal of Anatomy, EarlyView.
At 5 weeks of development, the midgut has formed its primary loop (left). It is well established that the midgut is bounded cranially by the caudal end of the ventral mesentery and the presence of the common bile duct, but its caudal boundary remains to be established.
Hui Gao, Nutmethee Kruepunga, Greet Mommen, Susanne E. Köhler, Jill P. J. M. Hikspoors, Wouter H. Lamers   +5 more
wiley   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source