Results 71 to 80 of about 2,270,919 (288)
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Description du développement de la politique de santé numérique tchadienne [PDF]
Pensées Genre, Penser AutrementLe développement de la politique de santé numérique recèle un potentiel considérable d’amélioration concernant les soins de santé et la vie des utilisateurs.
ALBASSAR Tiguetna Esaïe +1 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Ces Espaces autres entre rôles et enjeux : des espaces topiques aux espaces hétérotopiques dans La Chrysalide et Ciel de Porphyre d’Aicha Lemsine [PDF]
Revue Roumaine d’Etudes Francophones, 2020 Space represents an indispensable element in the progression of the narrative, and it is linked to the being and the becoming of the characters. It is also the reflection of their deep structure because the spaces, the places described and the intimate ...
Sihem GUETTAFI
doaj
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
, 2001 We present a first description and evaluation of GEOS-CHEM, a global three- dimensional (3-D) model of tropospheric chemistry driven by assimilated meteorological observations from the Goddard Earth Observing System (GEOS) of the NASA Data Assimilation ...
I. Bey +9 more
semanticscholar +1 more source
HGVS Recommendations for the Description of Sequence Variants: 2016 Update
Human Mutation, 2016 The consistent and unambiguous description of sequence variants is essential to report and exchange information on the analysis of a genome. In particular, DNA diagnostics critically depends on accurate and standardized description and sharing of the ...
J. T. Dunnen +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
The Human Connectome: A Structural Description of the Human Brain
PLoS Comput. Biol., 2005 The connection matrix of the human brain (the human “connectome”) represents an indispensable foundation for basic and applied neurobiological research.
O. Sporns, G. Tononi, R. Kötter
semanticscholar +1 more source