Results 51 to 60 of about 139,114 (288)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Screencast : promovendo o sucesso na disciplina de geometria descritiva [PDF]

, 2009
Nesta comunicação vamos apresentar um projecto inovador desenvolvido numa turma de 11º ano de escolaridade na disciplina de Geometria Descritiva. A Geometria Descritiva é uma disciplina com elevado grau de insucesso no exame nacional e, no sentido de ...
Coutinho, Clara Pereira, Rocha, Aurora Maria Moreira da   +1 more
core  

The Inhuman Overhang: On Differential Heterogenesis and Multi-Scalar Modeling [PDF]

, 2020
As a philosophical paradigm, differential heterogenesis offers us a novel descriptive vantage with which to inscribe Deleuze’s virtuality within the terrain of “differential becoming,” conjugating “pure saliences” so as to parse economies, microhistories,
Erkan, Ekin
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

THE DESIGN AND IMPLEMETATION OF THE RESEARCH CENTER FOR AERONAUTICS AND SPACE WEB SITE

Journal of Industrial Design and Engineering Graphics, 2010
This paper presents some elements and principles commonly used in web design. It’s addressed to anyone with an interest in developing their skills as a visual communicator, anyone who wants to learn the basics of graphical design, so they can develop ...
LEHADUS Daniel, SIMION Ionel
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Using the methods to descriptive geometry for decision applied problem cadastre of the land [PDF]

, 2010
На примерах показано применение методов начертательной геометрии для решения прикладных задач земельного кадастра.On example is shown using the methods to descriptive geometry for deci-sion applied problem cadastre of the ...
Добрынин, А. А., Ларионова, Р. М.   +1 more
core  

The Logic behind Feynman's Paths

, 2010
The classical notions of continuity and mechanical causality are left in order to refor- mulate the Quantum Theory starting from two principles: I) the intrinsic randomness of quantum process at microphysical level, II) the projective representations of ...
Boltzmann L., Born M., Cohen-Tannoudji C., EDGARDO T. GARCÍA ÁLVAREZ, Feynman R. P., Feynman R. P., Feynman R. P., Feynman R. P., Finkelstein D. R., García Álvarez E. T., Heisenberg W., Kolmogorov A. N., Messiah A., Sakurai J. J., Schwinger J., Schwinger J., Schwinger J., von Neumann J., Weyl H.   +18 more
core   +1 more source

INFLUENCE OF COLOR IN WEB-DESIGN

Journal of Industrial Design and Engineering Graphics, 2010
A web designer must use color in an efficient way that will present, on the internet, information, services, organizations and products. Colors have great impact on the human psyche.
IONEL Alexandru, PETRESCU Ligia
doaj  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source