Results 141 to 150 of about 639,728 (301)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Descriptive Norms and Prototypes Predict COVID-19 Prevention Cognitions and Behaviors in the United States: Applying the Prototype Willingness Model to Pandemic Mitigation. [PDF]
Ann Behav Med, 2021 Peterson LM +2 more
europepmc +1 more source
Scientific ReportsPrevious research suggests that descriptive norms positively influence proenvironmental behavior, including littering prevention. However, in some behavioral contexts, a weak descriptive norm may increase individuals’ feelings of responsibility by ...
Pengya Ai, Sonny Rosenthal
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Risk Management in Smallholder Cattle Farming: A Hypothetical Insurance Approach in Western Kenya [PDF]
Smallholder cattle farming is an important livelihood strategy in most developing countries like Kenya. However, tropical diseases in Africa often wipe out these valuable assets.
Drucker, Adam G. +4 more
core +1 more source
The role of emotion regulation in normative influence under uncertainty
BMC PsychologySocial norms are pivotal in guiding decision-making. Motives for following social norms are often described as gaining or avoiding (dis)approval and as an adaptive heuristic. We propose that social norms also serve an emotion-regulating function.
Magnus Bergquist, Malin Ekelund
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Starfished in the sand : developing the theory of planned behaviour to predict intentions to use sunscreen on the beach : a research project presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, Albany, Auckland, New Zealand [PDF]
, 2003 This study examined the predictive power of the theory of planned behaviour in explaining sunscreen use intentions among beach-goers in New Zealand (n = 148) and the United Kingdom (n = 280). Generally, the theory of planned behaviour performed well with
Neil, Tessa Anne
core