Results 81 to 90 of about 119,853 (293)

ℓ -Norm Support Vector Data Description

Pattern Recognition, 2022
The support vector data description (SVDD) approach serves as a de facto standard for one-class classification where the learning task entails inferring the smallest hyper-sphere to enclose target objects while linearly penalising the errors/slacks via an ℓ1-norm penalty term.
openaire   +4 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Social Norms: Interactions Between Descriptive and Injunctive Norms

In this iteration of our study of injunctive and descriptive norms we examine how different presentations of both descriptive and injunctive social norms messages affect the perception of the descriptive norm, the injunctive norm, the first and second ...
Benjamin Douglas
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

When Descriptive Norms Backfire

, 2017
We examine the positive and negative consequences of descriptive norms about preparedness against natural ...
Taku Ozaki
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Did Descriptive and Prescriptive Norms About Gender Equality at Home Change During the COVID-19 Pandemic? A Cross-National Investigation.

Using data from 15 countries, this article investigates whether descriptive and prescriptive gender norms concerning housework and child care (domestic work) changed after the onset of the COVID-19 pandemic.
Saxler, Franziska Magdalena, Danyliuk, Ivan, Dorrough, Angela R., Schmader, Toni, Germano, Adriana, Ishii, Keiko, Froehlich, Laura, Olsson, Maria, Gavreliuc, Alin, Meeussen, Loes, Cheryan, Sapna, Velásquez Díaz, Laura María, Birneanu, Andreea, Lapytskaia Aidy, Christina, Steele, Jennifer, Venegas, Mar, Croft, Alyssa, Estevan-Reina, Lucía, Block, Katharina, Benson-Greenwald, Tessa, Morandini, James, Cavojova, Vladimira, Steffens, Melanie C, Kundtová Klocová, Eva, Martiny, Sarah E, Scheifele, Carolin, Ramis, TamilSelvan, Eisner, Léïla, Kozytska, Inna, van Grootel, Sanne, Henningsen, Levke, López López, Wilson, Fedáková, Denisa, Schuster, Carolin, Martiny, Sarah E., Kulich, Clara, Gavreliuc, Dana, Dorrough, Angela R, Van Laar, Colette, Atkinson, Ciara, de Lemus, Soledad, Steffens, Melanie C., Dar-Nimrod, Ilan, Diekman, Amanda, Hässler, Tabea, Lee Kai Chung, Albert   +45 more
core   +1 more source

Breaking False Polarization: How Information on Descriptive Norms Mitigates Worry Rooted in Polarization (Mis)perceptions

Social Inclusion
Worry about polarization in society, particularly around the topic of immigration, is widespread despite the lack of substantial evidence supporting the existence of actual polarization of attitudes.
Tom Nijs
doaj   +1 more source