Results 101 to 110 of about 644,861 (303)

Local descriptive body weight and dietary norms, food availability, and 10-year change in glycosylated haemoglobin in an Australian population-based biomedical cohort

BMC Public Health, 2017
Background Individual-level health outcomes are shaped by environmental risk conditions. Norms figure prominently in socio-behavioural theories yet spatial variations in health-related norms have rarely been investigated as environmental risk conditions.
Suzanne J. Carroll, Catherine Paquet, Natasha J. Howard, Neil T. Coffee, Robert J. Adams, Anne W. Taylor, Theo Niyonsenga, Mark Daniel   +7 more
doaj   +1 more source

Open Science Practices are on the Rise: The State of Social Science (3S) Survey [PDF]

, 2020
Has there been meaningful movement toward open sci-ence practices within the social sciences in recent years? Discussions about changes in practices such as posting data and pre-registering analyses have been marked by controversy—including controversy ...
Birke, David, Christensen, Garret, Levy Paluck, Elizabeth, Littman, Rebecca, Miguel, Edward, Swanson, Nicholas, Wang, Zenan   +6 more
core  

1000 Norms Project: Protocol of a cross-sectional study cataloging human variation [PDF]

, 2015
Background Clinical decision-making regarding diagnosis and management largely depends on comparison with healthy or ‘normal’ values. Physiotherapists and researchers therefore need access to robust patient-centred outcome measures and appropriate ...
Baldwin, Jennifer N., Burns, Joshua, Chard, Angus, Ferreira, Paulo, Fong Yan, Alycia, Hiller, Claire E., Hübscher, Markus, Mackey, Martin G., McKay, Marnee J., Moloney, Niamh A., Mousavi, Seyed J., Nicholson, Leslie L., Nightingale, Elizabeth J., on behalf of the 1000 Norms Project Consortium, Pourkazemi, Fereshteh, Quinlan, Kate G., Raymond, Jacqueline, Refshauge, Kathryn M., Rose, Kristy, Simic, Milena, Sman, Amy D., Vanicek, Natalie, Wegener, Caleb   +22 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Descriptive norms and entrepreneurial intentions: the mediating role of anticipated inaction regret. [PDF]

Front Psychol, 2023
Bae TJ, Lee CK, Lee Y, McKelvie A, Lee WJ.   +4 more
europepmc   +1 more source

Understanding Legislator Experiences of Family-Friendly Working Practices in Political Institutions [PDF]

, 2016
This is a post-peer-review, pre-copy edit version of an article published in Politics and Gender.
Allen, P, Cutts, D, Winn, M
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Constructive Empiricism: Normative or Descriptive? [PDF]

International Journal of Philosophical Studies, 2014
In this paper, I argue that Constructive Empiricism (CE) is ambiguous between two interpretations: CE as a normative epistemology of science and CE as a descriptive philosophy of science. When they present CE, constructive empiricists write as if CE is supposed to be more than a normative epistemology of science and that it is meant to be responsible ...
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

ANALISIS PUTUSAN MAHKAMAH KONSTITUSI NOMOR 12/PUU-XXI/2023 TENTANG MANTAN NARAPIDANA SEBAGAI CALON LEGISLATIF DITINJAU DARI PERSPEKTIF HAK ASASI MANUSIA [PDF]

Article 182 letter g of Law Number 7 of 2017 concerning General Elections is contrary to article 28 D paragraph 1 of the 1945 Constitution and is inconsistent with the application of other election conditions.
Herniko, Rio Rizki
core