Results 111 to 120 of about 134,969 (309)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Fregean Description Theory in Proof-Theoretical Setting
Logic and Logical Philosophy, 2018 We present a proof-theoretical analysis of the theory of definite descriptions which emerges from Frege’s approach and was formally developed by Kalish and Montague. This theory of definite descriptions is based on the assumption that all descriptions are treated as genuine terms.
openaire +3 more sources
Applications of Descriptive Set Theory to Complex Analysis [PDF]
, 2021 Christopher Caruvana, Robert R. Kallman
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Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Al-Ta'ribThe Duolingo application offers foreign language learning, specifically Arabic, to learners worldwide. Although effective, the material within it must meet international language learning standards.
Muchsinul Khuluq +3 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Explanation in Descriptive Set Theory
Abstract In this paper we investigate explanatory proofs in mathematics. We do this via an extended case study from descriptive set theory. The aim is to shed light on what makes explanatory proofs explanatory. Building on earlier work, we argue that there may be more than one notion of explanation in operation in mathematics: there does
Carolin Antos, Mark Colyvan
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Some facts from descriptive set theory concerning essential spectra and applications [PDF]
, 2005 Khalid Latrach +2 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Topics in descriptive set theory related to equivalence relations, complex borel and analytic sets [PDF]
, 2017 Nikolaos E. Sofronidis
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