Results 111 to 120 of about 151,811 (297)

An overview of descriptive set theory

, 1979
Understanding the structure of sets of reals is one of the fundamental problems of set theory. Of course, an arbitrary subset of the continuum is immensely complicated, and exhibits in general no regularities.
Kechris, Alexander S.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Application of Kolcaba’s Comfort Theory in healthcare promoting adults’ comfort: a scoping review

BMJ Open
Background Comfort is a primary goal of healthcare. Theory-informed interventions and measurement are essential for comfort enhancement.Objectives To categorise and synthesise the international literature on the application of Kolcaba’s Comfort Theory in
Yi Zhou, Can Chen, Yanxia Lin, Chuchu Yan, Junyi Gu   +4 more
doaj   +1 more source

Set Theory (online meeting)

, 2020
Set theory continues to experience dramatic progress, both in pure set theory, with its fundamental techniques of forcing, large cardinals, and inner model theory, and in applied set theory, with its deep connections to other areas of mathematics ...

core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Axioms of set theory in descriptive set theory

This thesis deals with the role of set-theoretic axioms in descriptive set theory, focusing on the consequences of the existence of measurable cardinals. We first define some basic notions from descriptive set theory.
Banáš, Peter
core   +1 more source

Analysis of the quality of test instrument and students’ accounting learning competencies at vocational school

Jurnal Penelitian dan Evaluasi Pendidikan, 2019
The study is aimed at describing: (1) characteristics of the items of the national examination try-out test of the accounting subject matter in the 2015/2016 academic year on classical test theory and modern test theory; and (2) classification of ...
Nur Ichsanuddin Achmad Kurniawan, Sudji Munadi   +1 more
doaj   +1 more source

Descriptive Set Theory and the Ergodic Theory of Countable Groups [PDF]

, 2013
The primary focus of this thesis is on the interplay of descriptive set theory and the ergodic theory of group actions. This incorporates the study of turbulence and Borel reducibility on the one hand, and the theory of orbit equivalence and weak ...
Tucker-Drob, Robin Daniel
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source