Results 81 to 90 of about 2,014,608 (301)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Integrative-Interconnective Approach In Sets: A Teaching Material Development for Enhancing Students' Conceptual Understanding

open access: yesJournal for Lesson and Learning Studies
The low level of student understanding and the limited teaching materials that can link set theory with Islamic values are one of the main obstacles in mathematics learning at the madrasah level. This study aims to develop teaching materials in the form
Fadrik Adi Fahrudin   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Classical descriptive set theory as a refinement of effective descriptive set theory

open access: yesAnnals of Pure and Applied Logic, 2010
Abstract The (effective) Suslin–Kleene Theorem is obtained as a corollary of a standard proof of the classical Suslin Theorem, by noticing that it is mostly constructive and applying to it a naive realizability interpretation.
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

KOMUNIKASI PEMIMPIN PUSAT-DAERAH DI ERA REVOLUSI INDUSTRI 4.0

open access: yesJurnal Peurawi: Media Kajian Komunikasi Islam, 2019
Communication between central-regional leaders is a substance in building the Indonesian nation. The central leaders, both the President, the Minister, as well as the first and second echelon officials based in Jakarta, need a strategy in communicating ...
Abdul Rani Usman   +2 more
doaj   +1 more source

Ordinary differential equations and descriptive set theory: uniqueness and globality of solutions of Cauchy problems in one dimension

open access: yes, 1996
We study some natural sets arising in the theory of ordinary differential equations in one variable from the point of view of descriptive set theory and in particular classify them within the Borel hierarchy.
Andretta, Alessandro, Marcone, Alberto
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Characteristics of selected approaches of uncertainty modelling in the context of management sciences

open access: yesHumanities and Social Sciences, 2019
Information uncertainty in management systems is a subject of research of many scientific disciplines. Research concerning a quantitative modelling of uncertainty verging on mathematics, information technology, and logic is extremely important.
Rafał Mierzwiak
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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