Results 81 to 90 of about 11,781,613 (287)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

FROM REAL-LIFE TO VERY STRONG AXIOMS Classification problems in Descriptive Set Theory & regularity properties in Generalized Descriptive Set Theory [PDF]

, 2023
This thesis is divided into three parts, the first and second ones focused on combinatorics and classification problems on discrete and geometrical objects in the context of descriptive set theory, and the third one on generalized descriptive set theory ...
IANNELLA, MARTINA
core   +1 more source

ω-powers and descriptive set theory

Journal of Symbolic Logic, 2005
AbstractWe study the sets of the infinite sentences constructible with a dictionary over a finite alphabet, from the viewpoint of descriptive set theory. Among others, this gives some true co-analytic sets. The case where the dictionary is finite is studied and gives a natural example of a set at level ω of the Wadge hierarchy.
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Further Operations (Complement, Intersection, Union) for IndetermSoft Set, IndetermHyperSoft Set, and TreeSoft Set and their Applications

In this paper, efforts are intensified as much as possible to explicitly and clearly give the definitions as regards the operations involving the complement, intersection as well as the union for IndetermSoft Set, IndetermHyperSoft Set, and Tree Soft Set
Adesina, Adebisi Sunday
core   +1 more source

Topics in invariant descriptive set theory

Annals of Pure and Applied Logic, 2001
The author generalizes two concepts from special cases of Polish group actions on Polish spaces: the logic actions by the group~\(S_\infty\) (the group of permutations of~\(\mathbb N\)) on the set of codes for countable infinite \(L\)-structures where \(L\)~is a~countable relational language and the analytic sets (which are invariant with respect to ...
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

BARRIERS TO EMPLOYEE VOICE: THE INTERPLAY BETWEEN MUSHROOM MANAGEMENT AND WORK ALIENATION

KAÜ-İİBF Dergisi
The aim of this study is to reveal the role of work alienation (WA) in the effect of the mushroom management (MM) approach on employee voice (EV) within the framework of social exchange theory (SET) and learned helplessness theory (LHT).
Efekan Taha Özel, Ayla Zehra Öncer, Beril Durmuş   +2 more
doaj   +1 more source

Characteristics of selected approaches of uncertainty modelling in the context of management sciences

Humanities and Social Sciences, 2019
Information uncertainty in management systems is a subject of research of many scientific disciplines. Research concerning a quantitative modelling of uncertainty verging on mathematics, information technology, and logic is extremely important.
Rafał Mierzwiak
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source