Results 211 to 220 of about 2,288,448 (331)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Successful extracorporeal membrane oxygenation-bridged rituximab desensitization enabling blood type-incompatible living-donor lung transplantation. [PDF]

JTCVS Tech
Watanabe Y, Hirama T, Watanabe T, Oishi H, Akiba M, Mukai S, Saito M, Kumata S, Onodera K, Togo T, Notsuda H, Suzuki T, Niikawa H, Okada Y, Tohoku Lung Transplant Group.   +14 more
europepmc   +1 more source

Individuals with Autism Spectrum Disorders Have Equal Success Rate But Require Longer Periods of Systematic Desensitization than Control Patients to Complete Ambulatory Polysomnography

Journal of Clinical Sleep Medicine (JCSM), 2016
Michelle M. Primeau, A. Gershon, L. Talbot, Isabelle Cotto, L. Lotspeich, A. Hardan, J. Hallmayer, R. O’Hara   +7 more
semanticscholar   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Successful living kidney transplantation in a T-cell flow cytometry crossmatch-positive patient with atypical hemolytic uremic syndrome treated with an anti-C5 antibody: a case report. [PDF]

CEN Case Rep
Okumi M, Okuno N, Kurose R, Segawa Y, Komaki K, Miyashita M, Ueda T, Ukimura O, Tamagaki K.   +8 more
europepmc   +1 more source

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source

Designing an Incremental Egg Oral Immunotherapy Protocol: A Strategic Approach with Safety as a Priority

Journal of Asthma and Allergy
Darin Munyuen, Araya Yuenyongviwat, Pasuree Sangsupawanich, Kokaew Chauikaew, Burat Srisuk, Tidawan Chanklay, Vanlaya Koosakulchai Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai ...
Munyuen D, Yuenyongviwat A, Sangsupawanich P, Chauikaew K, Srisuk B, Chanklay T, Koosakulchai V   +6 more
doaj  

Etoposide Hypersensitivity Reactions in Pediatric Oncology: Understanding Mechanisms and Optimizing Management. [PDF]

Cancers (Basel)
Filippo M, Zicari AM, Cinicola BL, Capponi M, Granata L, Stefanachi F, Carosini S, Ferrozzi F, Amoroso L.   +8 more
europepmc   +1 more source

The structure of the skeletal muscle calcium channel [PDF]

, 1989
Berwe, Campbell, Chou, Curtis, Ellis, Flockerzi, Flockerzi, Galizzi, Garnier, Hofmann, Hymel, Ildefonse, Jahn, Kaczmarek, Lamb, Leung, Ma, Morton, Nastainczyk, Nowycky, O'Callahan, Pelzer, Rios, Röhrkasten, Schneider, Sieber, Striessnig, Striessnig, Striessnig, Takahashi, Talvenheimo, Tanabe, Tanabe, Trautwein, Vilven, Yatani, Yatani   +36 more
core   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source