Results 21 to 30 of about 160,901 (261)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Desenvolvimento e Meio AmbienteEquipe Editorial e Técnica deste volume / Editorial and technical team for this volume: Editores-chefes / Editors-in-chief: Manuela Dreyer Silva e Letícia da Costa e Silva Editores adjuntos / Associate editors: Angela Duarte Damasceno Ferreira,
Editores Desenvolvimento e Meio Ambiente
doaj +1 more source
O problema contemporâneo do desenvolvimento: situação presente e antecedentes históricos
Revista de História, 1969 O tema desta aula foi escolhido com o propósito de expôr e ilustrar o ponto de vista de que a história econômica pode constituir um instrumento complementar de análise dos fenômenos contemporâneos de caráter econômico, em particular daqueles de mais ...
Nuno Fidelino de Figueiredo
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Psicologia em Estudo, 2006 O presente estudo teve como objetivo analisar a produção científica do período de 1998 a 2004, relacionada à interação entre mães e crianças nascidas pré-termo e seu desenvolvimento nas fases pré-escolar e escolar.
Vivian Caroline Klein +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2014 This study aimed to evaluate the biotic potential, life table parameters and fertility of Spodoptera albula (Walker, 1857) under controlled conditions (25 ± 1°C, 70 ± 10% RH and 14 hour photo phase).
DÉBORA G. MONTEZANO +8 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Sociedade e Estado, 2009 Este trabalho objetiva analisar as relações entre ciências sociais e saúde pública no Brasil, privilegiando o papel de sociólogos e antropólogos que se colocaram na posição de "tradutores" entre os profissionais de saúde e as populações rurais objeto da ...
Marcos Chor Maio +1 more
doaj +1 more source