Results 31 to 40 of about 159,348 (259)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Ficha Técnica da Edição

Desenvolvimento e Meio Ambiente
Equipe Editorial e Técnica deste volume / Editorial and technical team for this volume:   Editores-chefes / Editors-in-chief: Manuela Dreyer Silva e Letícia da Costa e Silva Editores adjuntos / Associate editors: Angela Duarte Damasceno Ferreira,
Editores Desenvolvimento e Meio Ambiente
doaj   +1 more source

Avanços na compreensão da relação entre temperamento e comportamento anti-social

INFAD, 2015
Este artigo constitui uma síntese compreensiva de contributos teóricos e empíricos acerca da relação entre o temperamento e o comportamento anti-social.
Sonia Mairos Ferreira
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

O problema contemporâneo do desenvolvimento: situação presente e antecedentes históricos

Revista de História, 1969
O tema desta aula foi escolhido com o propósito de expôr e ilustrar o ponto de vista de que a história econômica pode constituir um instrumento complementar de análise dos fenômenos contemporâneos de caráter econômico, em particular daqueles de mais ...
Nuno Fidelino de Figueiredo
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Prematuridade e interação mãe-criança: revisão sistemática da literatura Prematuridad e interacción madre-niño: revisión sistemática de la literatura Prematurity and mother-child interaction: a systematic bibliographycal review

Psicologia em Estudo, 2006
O presente estudo teve como objetivo analisar a produção científica do período de 1998 a 2004, relacionada à interação entre mães e crianças nascidas pré-termo e seu desenvolvimento nas fases pré-escolar e escolar.
Vivian Caroline Klein, Maria Beatriz Martins Linhares   +1 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Biotic potential, fertility and life table ofSpodoptera albula (Walker) (Lepidoptera: Noctuidae), under controlled conditions

Anais da Academia Brasileira de Ciências, 2014
This study aimed to evaluate the biotic potential, life table parameters and fertility of Spodoptera albula (Walker, 1857) under controlled conditions (25 ± 1°C, 70 ± 10% RH and 14 hour photo phase).
DÉBORA G. MONTEZANO, ALEXANDRE SPECHT, DANIEL R. SOSA-GÓMEZ, VÂNIA F. ROQUE-SPECHT, TARCISO M. BORTOLIN, EDEGAR FRONZA, PATRÍCIA PEZZI, PRISCILA C. LUZ, NEIVA M. BARROS   +8 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source