Results 1 to 10 of about 11,188 (157)

Esquema conceitual no desenvolvimento de novos produtos sustentáveis

Revista de Gestão e Secretariado, 2022
O presente estudo objetivou apresentar um esquema conceitual por meio de uma revisão sistemática das melhores práticas de desenvolvimento de novos produtos sustentáveis (DNPS) conjuntamente com o que já está consolidado na literatura sobre desenvolvimento de novos produtos (DNP), propondo a inclusão da dimensão sustentabilidade. Ficou evidenciado que o
Vera Lúcia Cruz, Sheila Trícia Guedes Pastana, Cristine Hermann Nodari, Luiz Antonio Felix Júnior   +3 more
openaire   +4 more sources

Synthesis, SAR, and Docking Studies Disclose 2‐Arylfuran‐1,4‐naphthoquinones as In Vitro Antiplasmodial Hits

Journal of Tropical Medicine, Volume 2017, Issue 1, 2017., 2017
A total of 28 lapachol‐related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine‐resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method.
Tatiane Freitas Borgati, Maria Fernanda Alves do Nascimento, Juma Fortunato Bernardino, Lunamaura Claudia Oliveira Martins, Alex Gutterres Taranto, Alaíde Braga de Oliveira, Marcel Tanner   +6 more
wiley   +1 more source

Inovação colaborativa: uma abordagem aberta no desenvolvimento de novos produtos [PDF]

Revista de Administração de Empresas, 2012
As estratégias que as empresas têm adotado para promover inovações tecnológicas de produtos e serviços vêm mudando significativamente nos últimos anos. Um dos elementos de notável evolução diz respeito à maneira como as empresas conduzem a etapa de pesquisa e desenvolvimento (P&D) de novos produtos, serviços, processos e modelos de negócios. Diante
Bueno, Bruna, Balestrin, Alsones
openaire   +4 more sources

Antimicrobial, Antioxidant, Anti‐Inflammatory, and Cytotoxic Activities of Propolis from the Stingless Bee Tetragonisca fiebrigi (Jataí)

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Propolis from stingless bees Tetragonisca fiebrigi found in Brazil is used in folk medicine by their nutritional and therapeutic properties. However, there are no scientific records evidencing such properties. The present study was designed to investigate the chemical composition and the biological properties of propolis from T. fiebrigi. For this, the
Jaqueline Ferreira Campos, Uilson Pereira dos Santos, Paola dos Santos da Rocha, Marcio José Damião, José Benedito Perrella Balestieri, Claudia Andrea Lima Cardoso, Edgar Julian Paredes-Gamero, Leticia Miranda Estevinho, Kely de Picoli Souza, Edson Lucas dos Santos, Vincenzo De Feo   +10 more
wiley   +1 more source

Pharmacological Basis for Traditional Use of the Lippia thymoides

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The aim of this study was to evaluate crude extracts and fractions from leaves and stems of Lippia thymoides and to validate their use in folk medicine. In vitro antioxidant and antimicrobial activities and in vivo wound healing in rats, baker yeast‐induced fever in young rats, and acute oral toxicity in mice assays were realized.
Fabrício Souza Silva, Pedro Modesto Nascimento Menezes, Pedro Guilherme Souza de Sá, André Luís de Santana Oliveira, Eric Alencar Araújo Souza, Vinicius Martins Bamberg, Henrique Ribeiro de Oliveira, Sheilla Andrade de Oliveira, Roni Evêncio e Araújo, Ana Paula Trovatti Uetanabaro, Tânia Regina dos Santos Silva, Jackson Roberto Guedes da Silva Almeida, Angélica Maria Lucchese, Daniela Rigano   +13 more
wiley   +1 more source

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Ocotea notata from Brazilian Restinga

The Scientific World Journal, Volume 2015, Issue 1, 2015., 2015
The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this genus as O. puberula and O. quixos have been described in the literature, showing antibacterial activity. And Ocotea macrophylla showed anti‐inflammatory activity with inhibition of COX‐1, COX‐2, and LOX‐5.
Isabela Francisca Borges Costa, Sanderson Dias Calixto, Marlon Heggdorne de Araujo, Tatiana Ungaretti Paleo Konno, Luzineide Wanderley Tinoco, Denise Oliveira Guimarães, Elena B. Lasunskaia, Ivana Ramos Correa Leal, Michelle Frazão Muzitano, Wanchai De-Eknamkul   +9 more
wiley   +1 more source

Promoting Nerve Regeneration in a Neurotmesis Rat Model Using Poly(DL‐lactide‐ε‐caprolactone) Membranes and Mesenchymal Stem Cells from the Wharton’s Jelly: In Vitro and In Vivo Analysis

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
In peripheral nerves MSCs can modulate Wallerian degeneration and the overall regenerative response by acting through paracrine mechanisms directly on regenerating axons or upon the nerve‐supporting Schwann cells. In the present study, the effect of human MSCs from Wharton’s jelly (HMSCs), differentiated into neuroglial‐like cells associated to poly ...
T. Pereira, A. Gärtner, I. Amorim, A. Almeida, A. R. Caseiro, Paulo A. S. Armada-da-Silva, Sandra Amado, Federica Fregnan, A. S. P. Varejão, J. D. Santos, P. J. Bartolo, S. Geuna, A. L. Luís, A. C. Mauricio, Manoor Prakash Hande   +14 more
wiley   +1 more source

Effects of Human Mesenchymal Stem Cells Isolated from Wharton’s Jelly of the Umbilical Cord and Conditioned Media on Skeletal Muscle Regeneration Using a Myectomy Model

Stem Cells International, Volume 2014, Issue 1, 2014., 2014
Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated with different vehicles to induce ...
T. Pereira, P. A. S. Armada-da Silva, I. Amorim, A. Rêma, A. R. Caseiro, A. Gärtner, M. Rodrigues, M. A. Lopes, P. J. Bártolo, J. D. Santos, A. L. Luís, A. C. Maurício, Pranela Rameshwar   +12 more
wiley   +1 more source

Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti‐Infective Agents

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new ...
Cristiana da Purificação Pinto, Velize Dias Rodrigues, Fernanda da Purificação Pinto, Renata da Purificação Pinto, Ana Paula Trovatti Uetanabaro, Carla Santos Ribeiro Pinheiro, Suzana Ferreira Magalhães Gadea, Tânia Regina dos Santos Silva, Angélica Maria Lucchese, Vincenzo De Feo   +9 more
wiley   +1 more source

Gene Co‐Expression Networks Highlight Key Nodes Associated With Ammonium Nitrate in Sugarcane

Physiologia Plantarum, Volume 177, Issue 6, November/December 2025.
ABSTRACT This study aimed to investigate molecular mechanisms underlying nitrogen use efficiency (NUE) in sugarcane by analyzing transcriptome profiles of two genotypes (responsive, RB975375; non‐responsive, RB937570) under contrasting nitrogen conditions, and along the leaf development gradient.
Jorge Mario Muñoz‐Pérez, Denis Bassi, Lucia Mattiello, Marcelo Menossi, Diego Mauricio Riaño‐Pachón   +4 more
wiley   +1 more source