Results 1 to 10 of about 235,424 (288)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2019 Par Louis Manière, ingénieur d'étude, responsable de la création du SIG du projet Desert Networks (CNRS, HiSoMA, Lyon) L'un des objectifs du projet ERC Desert Networks est la compréhension et la reconstitution des itinéraires antiques qui ont permis ...
Desert Networks
core
The influence of ambient conditions on a person's socio-political maturation: Example of the blessed Muhammad: A citizen of the world par excellence [PDF]
Kom: Časopis za Religijske NaukeIn the paper, we plan to examine how different ambient conditions and social conditioning affect a person's socio-political maturation in layers, to such an extent that sometimes the mentioned maturations are not only not identical, but almost not even ...
Dizdarević Bajram, Efendić Davud
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Editorial: Fire regimes in desert ecosystems: Drivers, impacts and changes
Frontiers in Ecology and Evolution, 2022 Eddie J. B. van Etten +3 more
doaj +1 more source
Politics, Philosophy & Economics, 2018 It is sometimes claimed that those who succeed with the aid of enhancement technologies deserve the rewards associated with their success less, other things being equal, than those who succeed without the aid of such technologies. This claim captures some widely held intuitions, has been implicitly endorsed by participants in social–psychological ...
openaire +3 more sources
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
, 2008 Livelihoods of the wider community in desert Australia are under pressure and some of the proposals explored in this report may assist small businesses and Aboriginal Australians to advance their livelihoods.
Davies, J +3 more
core