Results 71 to 80 of about 27,683 (245)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Humidity response depends on the small soluble protein Obp59a in Drosophila
eLife, 2018 Hygrosensation is an essential sensory modality that is used to find sources of moisture. Hygroreception allows animals to avoid desiccation, an existential threat that is increasing with climate change.
Jennifer S Sun +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Characterization of polyphenols in leaves of four desiccation tolerant plant families [PDF]
, 2005 Includes bibliographical references.Polyphenols in plants are known to act as antioxidants, antimicrobials, antifungal, photoreceptors, visual attractors and as light screens.
Dzobo, Kevin
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
The role of a Polyphenol from Myrothamnus flabellifolius in the protection of membranes during desiccation-using liposomes as a model membrane system [PDF]
, 2002 Includes bibliographical references.A deficiency of water is a common stress experienced by plants. Dehydration of plant tissue results in altered protein and lipid ultrastructure responsible for membrane stabilisation leading inevitably to the death of ...
Westalle, Kim Louise
core +1 more source
Investigation on Bacterial Desiccation*
Journal of Investigative Dermatology, 1955 The work of Norton and Novy (1, 2), and especially the conclusive investi-v gations of Pillsbury and Rebell (3), experimentally established the major role of desiccation in the mechanism of bacterial disappearance. According to * Pillsbury and associates the disappearance of various bacteria placed on healthy skin or glass surfaces is almost complete ...
Miescher, G. +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source