Results 191 to 200 of about 56,912 (284)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

ABA-GA antagonism and modular gene networks cooperatively drive acquisition of desiccation tolerance in perilla seeds. [PDF]

Front Plant Sci
Yang X, Chen M, Liu M, Li B, Sun Z, Lu A, Zhang S, Shi X, Ren J, Qin X, Ma J.   +10 more
europepmc   +1 more source

Gene expression differences consistent with water loss reduction underlie desiccation tolerance of natural Drosophila populations. [PDF]

BMC Biol, 2023
Horváth V, Guirao-Rico S, Salces-Ortiz J, Rech GE, Green L, Aprea E, Rodeghiero M, Anfora G, González J.   +8 more
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Red-light signaling pathway activates desert cyanobacteria to prepare for desiccation tolerance. [PDF]

Proc Natl Acad Sci U S A
Xu HF, Dai GZ, Li RH, Bai Y, Zuo AW, Zhao L, Cui SR, Shang JL, Cheng C, Wang YJ, Feng GF, Duanmu D, Kaplan A, Qiu BS.   +13 more
europepmc   +1 more source

Intra-Specific Variation in Desiccation Tolerance of Citrus sinensis 'bingtangcheng' (L.) Seeds under Different Environmental Conditions in China. [PDF]

Int J Mol Sci, 2023
Chen H, Visscher AM, Ai Q, Yang L, Pritchard HW, Li W.   +5 more
europepmc   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Surviving water scarcity: seasonal contrasts in drought and desiccation tolerance of co-occurring <i>Barbacenia gentianoides</i> and <i>Vellozia caruncularis</i>. [PDF]

Front Plant Sci
Vieira EA, da Silva GM, Gaspar M, Braga MR, Caldeira CF.   +4 more
europepmc   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Desiccation tolerance in peatland desmids: a comparative study of Micrasterias thomasiana and Staurastrum hirsutum (Zygnematophyceae). [PDF]

Protoplasma
Nemcova Y, Neustupa J, Pichrtová M.
europepmc   +1 more source