Results 51 to 60 of about 4,589,695 (260)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Mediendidaktische Prinzipien in der Praxis

open access: yesMedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Um sich im dynamischen modernen Bildungssystem zurechtzufinden, benötigen Lehrpersonen neben fachspezifischen Kompetenzen auch bereichsübergreifende Kompetenzen, darunter wichtige sozial-emotionale Fähigkeiten wie Resilienz.
Isabelle Krummenacher   +2 more
doaj   +1 more source

The Legitimization of Improvement Science in Academe [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2019
This article examines improvement science (Bryk, 2009) against the backdrop of traditional academic research methods. Improvement science is perhaps most closely aligned with design-based implementation research, and is typically applied to networked ...
Casey D. Cobb, Patricia Virella
doaj  

A Learning Activity Design Framework for Supporting Mobile Learning

open access: yesDesigns for Learning, 2016
This article introduces the Learning Activity Design (LEAD) framework for the development and implementation of mobile learning activities in primary schools.
Jalal Nouri   +2 more
doaj   +1 more source

Design-Based Research - A Research Format for Educational Research

open access: yesVietnam Journal of Education
In educational research, the gap between university research and school practice is frequently pointed out. Particularly, the transfer of innovative scientific research findings into teaching practice occurs far too rarely or too late. Although theorists and teachers recognize and criticize the problem of theory-practice transfer, there are still few ...
Kati Barthmann   +2 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Lehren und Lernen über Künstliche Intelligenz

open access: yesMedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Um Studierende auf die Herausforderungen vorzubereiten, die Künstliche Intelligenz (KI) in Alltag, Studium und Beruf mit sich bringt, werden an der Hochschule Offenburg Module zu KI-Themen umgesetzt und in einem Design-Based-Research-Prozess ...
Daniela Schlemmer   +5 more
doaj   +1 more source

Technology enhanced learning in science: interactions, affordances and design based research

open access: yesJournal of Interactive Media in Education, 2010
The role of an educational technologist is difficult to define. This paper reflects on the experience of working on a range of technology enhanced learning in science projects to review a number of working principles which have proved effective in the ...
Eileen Scanlon
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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