Results 91 to 100 of about 4,587,582 (217)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The Concorde and aeronautical research [PDF]
Theoretical and experimental work carried out in various research centers, and particularly at ONERA, which led to the conception and to the main technical solutions included in the design of Concorde: plane form, twist and camber of the wing, lift ...
Salmon, M.
core +1 more source
Crafting sustainable repairs: practice-based approaches to extending the life of clothes [PDF]
, 2015 Mass-produced ‘fast fashion’ has changed our relationship with clothing – cheap and easy to acquire, we are unlikely to take time to undertake simple repairs or address issues of maintenance, often caused or exacerbated by poor construction and low ...
McLaren, A, Mclauchlan, S
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Multiple confounders and complex entanglements: two case studies from design-led research for infection prevention and control educational tools. [PDF]
, 2018 Anti-microbial resistance (AMR) is an established and growing challenge in developed and developing countries around the world. Effective infection prevention and control (IPC) is essential for tackling the AMR problem. The uptake of appropriate IPC is heavily influenced by human risk perception and consequent behaviour and the way humans (and animals)
openaire
Is good enough 'making do'?: An investigation of inappropriate processing in a small design and build company [PDF]
, 2012 Purpose: The aim was to address behaviour that led to inappropriate processing in a small design and build contracting organisation that employs direct labour. The objective was to reduce process waste and improve the value delivered to clients.
Emmitt, S, Mertia, B, Pasquire, C
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Feeding the three headed monster of Higher Education [PDF]
, 2010 The integrated Taught Postgraduate framework (PGT) at Northumbria University supports a range of postgraduate programmes in design disciplines, design management and design practice by distance learning as well as professional doctorates.
English, Stuart, MacLarty, Liz
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